ArticleRetina (Philadelphia, Pa.)2013
Safety and efficacy of oral fluorescein angiography in detecting macular edema in comparison with spectral-domain optical coherence tomography.
Article in Retina (Philadelphia, Pa.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Orally administered fluorescein angiography for ultra-wide-field imaging: is a safe and effective modality across different age groups and fundus diseases?Frontiers in cell and developmental biology · 2025Article
- Non-invasive fluorescence sensing reveals changes in intestinal barrier function and gastric emptying rate in a first-in-human study of Crohn's disease.Therapeutic advances in gastroenterology · 2025Article
- Bibliometric analysis of ophthalmic OCT and OCT angiography research trends over the past 20 years.International ophthalmology · 2024Article
- Multifocal electroretinographic findings in angiographic macular leakage in the setting of intermediate, posterior, or panuveitis.Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2024Article
- Are optical coherence tomography and fluorescein angiography comparable for detection of macular edema in Behçet uveitis?Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Article
- Safety and Efficacy of Prostaglandin Analogues in the Immediate Postoperative Period after Uneventful Phacoemulsification.Vision (Basel, Switzerland) · 2023Article
- Fundus fluorescein angiography via percutaneous endoscopic gastrostomy: Description of technique.American journal of ophthalmology case reports · 2023Article
- Recommended protocol and technique for doing oral fundus fluorescein angiography for adults and children.Indian journal of ophthalmology · 2022Article
- Oral Fluorescein Angiography with Ultra-Wide-Field Scanning Laser Ophthalmoscopy in Pediatric Patients Precis: Oral Fluorescein Angiography in Children.Journal of clinical medicine · 2022Article
- The Utility of Fundus Fluorescein Angiography in Neuro-Ophthalmology.Neuro-ophthalmology (Aeolus Press) · 2019Review
- Advanced imaging for the diagnosis of age-related macular degeneration: a case vignettes study.Clinical & experimental optometry · 2018Article
- Selective and complementary use of Optical Coherence Tomography and Fluorescein Angiography in retinal practice.Eye and vision (London, England) · 2016Review
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo evaluate the safety of oral fluorescein angiography (FA) and to compare its efficacy in detection of macular edema (ME) with spectral-domain optical coherence tomography (SD-OCT).
methodsResults of imaging studies for 1,928 eyes of 1,019 patients who had simultaneously undergone both oral FA and SD-OCT by a confocal laser ophthalmoscope were reviewed. Sensitivity in detecting ME, discrepancy rate, and "kappa" agreement were determined for both the techniques and with eyes stratified by disease diagnosis.
resultsNo allergic reactions occurred after oral FA. Mild gastric discomfort was noted in <1% of the patients; 1,840 eyes (95.4%) showed concordance between the two techniques, and kappa agreement was 90.3%. For ME, oral FA showed an overall sensitivity of 0.97 and SD-OCT of 0.91. Equivalent sensitivity was found in cases of wet age-related macular degeneration (0.99). Oral FA was more sensitive than SD-OCT in cases of retinovascular diseases. The SD-OCT showed higher sensitivity in cases of macular holes. Detection of ME by SD-OCT was significantly higher in cases of intense leakage on oral FA (P < 0.001).
conclusionOral FA proved to be a safe and an adequate technique to evaluate ME. It is more sensitive than SD-OCT in detection of ME in cases of retinovascular diseases but can fail to detect ME in cases of macular holes. A noninvasive examination with simultaneous oral FA and SD-OCT may be considered to obtain a comprehensive evaluation of the presence of ME from different pathologies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.