ReviewCellular and molecular neurobiology2013
Effects of antiepileptic drugs on antioxidant and oxidant molecular pathways: focus on trace elements.
Review in Cellular and molecular neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 111 citations in OpenAlex.
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- Proteome-wide Mendelian randomization identified potential drug targets for migraine.The journal of headache and pain · 2024Article
- The Hepatoprotective Effects ofLife (Basel, Switzerland) · 2024Article
- Influence of Long-Term Anti-Seizure Medications on Redox Parameters in Human Blood.Pharmaceuticals (Basel, Switzerland) · 2024Article
- UtilizingFrontiers in nutrition · 2023Article
- Research progress on correlations between trace element levels and epilepsy.Frontiers in cell and developmental biology · 2023Review
- Levetiracetam Mechanisms of Action: From Molecules to Systems.Pharmaceuticals (Basel, Switzerland) · 2022Review
- The Interconnected Mechanisms of Oxidative Stress and Neuroinflammation in Epilepsy.Antioxidants (Basel, Switzerland) · 2022Review
- Antioxidative response of lettuce (Lactuca sativa) to carbamazepine-induced stress.Environmental science and pollution research international · 2021Article
- Topiramate Reverses Physiological and Behavioral Alterations by Postoperative Cognitive Dysfunction in Rat Model Through Inhibiting TNF Signaling Pathway.Neuromolecular medicine · 2020Article
- Inhibitions of anandamide transport and FAAH synthesis decrease apoptosis and oxidative stress through inhibition of TRPV1 channel in an in vitro seizure model.Molecular and cellular biochemistry · 2019Article
- Relative bioavailability of ultrafine sodium selenite for broilers fed a conventional corn-soybean meal diet.Journal of animal science · 2018Article
- Topiramate exhibits anti-tumorigenic and metastatic effects in ovarian cancer cells.American journal of translational research · 2018Article
- Serum Total Antioxidant Capacity of Epileptic Children before and after Monotherapy with Sodium Valproate, Carbamazepine, and Phenobarbital.Iranian journal of child neurology · 2018Article
- Topiramate as a neuroprotective agent in a rat model of spinal cord injury.Neural regeneration research · 2017Article
- Topiramate via NMDA, AMPA/kainate, GABAJournal of neural transmission (Vienna, Austria : 1996) · 2017Article
- Topiramate Improves Neuroblast Differentiation of Hippocampal Dentate Gyrus in the D-Galactose-Induced Aging Mice via Its Antioxidant Effects.Cellular and molecular neurobiology · 2017Article
- Selenium attenuates apoptosis, inflammation and oxidative stress in the blood and brain of aged rats with scopolamine-induced dementia.Metabolic brain disease · 2017Article
- Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance.Molecules (Basel, Switzerland) · 2017Review
- Protective Effect of Nerolidol Against Pentylenetetrazol-Induced Kindling, Oxidative Stress and Associated Behavioral Comorbidities in Mice.Neurochemical research · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current reports on trace elements, oxidative stress, and the effect of antiepileptic drugs are poor and controversial. We aimed to review effects of most common used antiepileptics on antioxidant, trace element, calcium ion (Ca(2+)) influx, and oxidant systems in human and experimental animal models. Observations of lower blood or tissue antioxidant levels in epileptic patients and animals compared to controls in recent publications may commonly support the proposed crucial role of antioxidants in the pathogenesis of epilepsy. Effects of old and new antiepileptics on reactive oxygen species (ROS) production in epilepsy are controversial. The old antiepileptic drugs like valproic acid, phenytoin, and carbamazepine induced ROS overproduction, while new epileptic drugs (e.g., topiramate and zonisamide) induced scavenger effects on over production of ROS in human and animals. Antioxidant trace element levels such as selenium, copper, and zinc were generally low in the blood of epileptic patients, indicating trace element deficiencies in the pathogenesis of epilepsy. Recent papers indicate that selenium with/without topiramate administration in human and animals decreased seizure levels, although antioxidant values were increased. Recent studies also reported that sustained depolarization of mitochondrial membranes, enhanced ROS production and Ca(2+) influx may be modulated by topiramate. In conclusion, there is a large number of recent studies about the role of antioxidants or neuroprotectants in clinical and experimental models of epilepsy. New antiepileptic drugs are more prone to restore antioxidant redox systems in brain and neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.