Trial reportPsychopharmacology2013
Alcohol attenuates amygdala-frontal connectivity during processing social signals in heavy social drinkers: a preliminary pharmaco-fMRI study.
Trial report in Psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood.Developmental cognitive neuroscience · 2022Pooled it
- Effects of acute alcohol consumption on hostile attribution bias towards emotional facial expressions and implicit approach/avoidance tendencies.Journal of psychopharmacology (Oxford, England) · 2026Trial
- Emotion perception and online awareness following alcohol-intoxication: investigating possible deficits using the complex audio visual emotion assessment task.Psychopharmacology · 2025Trial
- Ventral prefrontal network response to alcohol in young adults with bipolar disorder: a within-subject randomized placebo-controlled alcohol administration study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Low versus high level of response to alcohol affects amygdala functional connectivity during processing of emotional stimuli.Alcoholism, clinical and experimental research · 2022Trial
- Exogenous ghrelin administration increases alcohol self-administration and modulates brain functional activity in heavy-drinking alcohol-dependent individuals.Molecular psychiatry · 2018Trial
- Normalizing effect of heroin maintenance treatment on stress-induced brain connectivity.Brain : a journal of neurology · 2015Trial
- Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Cannabinoid modulation of amygdala subregion functional connectivity to social signals of threat.The international journal of neuropsychopharmacology · 2014Trial
- Decoding the serotonin-alcohol crosstalk: the role of central serotonergic dysregulation in alcohol use disorder.Pharmacological reports : PR · 2026Review
- Self-Protection Motivation and Its Psychological Construction: A Process Model Distinguishing Two Unique Motivational Orientations.Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc · 2026Review
- Alcohol misuse and negative emotion processing in neurotypical drinkers: Sex differences in behavioral and neural markers.Psychiatry research. Neuroimaging · 2026Article
- Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework.Psychopharmacology · 2026Review
- Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder.Nature communications · 2026Article
- Altered effective connectivity of emotion perception and regulation networks during an emotional face perception task in adults with alcohol use disorder.Brain structure & function · 2025Article
- Functional brain connectivity of the salience network in alcohol use and anxiety disorders.Journal of affective disorders · 2025Article
- The Dopamine System in Mediating Alcohol Effects in Humans.Current topics in behavioral neurosciences · 2025Review
- Re-evaluating our focus in addiction: emotional dysregulation is a critical driver of relapse to drug use.Translational psychiatry · 2024Review
- A longitudinal study of the relationship between alcohol-related blackouts and attenuated structural brain development.Developmental cognitive neuroscience · 2024Article
- Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk.Journal of the American College of Cardiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
rationaleConvergent evidence shows that alcohol exerts its effects on social behavior via modulation of amygdala reactivity to affective stimuli. Given that affective processing involves dynamic interactions between the amygdala and the prefrontal cortex (PFC), alcohol's effects are likely to extend beyond regional changes in brain activity to changes that manifest on a broader functional circuit level.
objectiveThe current study examines alcohol's effects on functional connectivity (i.e., "coupling") between the amygdala and the PFC during the processing of socio-emotional stimuli using functional magnetic resonance imaging (fMRI).
methodsIn a randomized, double blind, placebo-controlled, within-subjects cross-over design, 12 heavy, social drinkers performed an fMRI task designed to probe amygdala response to socio-emotional stimuli (angry, fearful, and happy faces) following acute ingestion of alcohol or placebo. Functional connectivity between the amygdala and PFC was examined and compared between alcohol and placebo sessions using a conventional generalized psychophysiological interaction (gPPI) analysis.
resultsRelative to placebo, alcohol reduced functional coupling between the amygdala and the right orbitofrontal cortex (OFC) during processing of both angry and fearful faces. Alcohol also reduced functional coupling between the amygdala and left OFC during processing of happy faces.
conclusionsThese preliminary findings suggest that alcohol's effects on social behavior may be mediated by alternations in functional connectivity between the amygdala and OFC during processing of emotional faces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.