ArticleScientific reports2013
Mass spectrometry imaging for in situ kinetic histochemistry.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Progress in monitoring molecular, cellular and metabolic dynamics using mass spectrometry imaging.Bioanalysis · 2025Review
- Spatio-Temporal Study of Galactolipid Biosynthesis in Duckweed Using Mass Spectrometry Imaging and in vivo Isotope Labeling.Plant & cell physiology · 2024Article
- Mass spectrometry imaging ofFrontiers in plant science · 2024Article
- Recent Developments and Application of Mass Spectrometry Imaging in N-Glycosylation Studies: An Overview.Mass spectrometry (Tokyo, Japan) · 2024Review
- Enablers and challenges of spatial omics, a melting pot of technologies.Molecular systems biology · 2023Review
- Using mass spectrometry imaging to map fluxes quantitatively in the tumor ecosystem.Nature communications · 2023Article
- Highlighting Functional Mass Spectrometry Imaging Methods in Bioanalysis.Journal of proteome research · 2022Review
- Reprogramming of Plant Central Metabolism in Response to Abiotic Stresses: A Metabolomics View.International journal of molecular sciences · 2022Review
- A revisit to staining reagents for neuronal tissues.Annals of eye science · 2022Article
- Following de novo triglyceride dynamics in ovaries of Aedes aegypti during the previtellogenic stage.Scientific reports · 2021Article
- Identification of Metabolically QuiescentmBio · 2021Article
- Applications of stable isotopes in MALDI imaging: current approaches and an eye on the future.Analytical and bioanalytical chemistry · 2021Review
- Improving Algorithm for the Alignment of Consecutive, Whole-Slide, Immunohistochemical Section Images.Journal of pathology informatics · 2021Article
- A methodological approach to correlate tumor heterogeneity with drug distribution profile in mass spectrometry imaging data.GigaScience · 2020Article
- Reshaping Lipid Biochemistry by Pushing Barriers in Structural Lipidomics.Angewandte Chemie (International ed. in English) · 2019Review
- Optical imaging of metabolic dynamics in animals.Nature communications · 2018Article
- A Phytochemical-Sensing Strategy Based on Mass Spectrometry Imaging and Metabolic Profiling for Understanding the Functionality of the Medicinal Herb Green Tea.Molecules (Basel, Switzerland) · 2017Review
- Imaging regiospecific lipid turnover in mouse brain with desorption electrospray ionization mass spectrometry.Journal of lipid research · 2017Article
- Detection of Localized Hepatocellular Amino Acid Kinetics by using Mass Spectrometry Imaging of Stable Isotopes.Angewandte Chemie (International ed. in English) · 2017Article
- Ultra-High Mass Resolution MALDI Imaging Mass Spectrometry of Proteins and Metabolites in a Mouse Model of Glioblastoma.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Tissues are composed of diverse cell subpopulations each with distinct metabolic characteristics that influence overall behavior. Unfortunately, traditional histopathology imaging techniques are 'blind' to the spatially ordered metabolic dynamics within tissue. While mass spectrometry imaging enables spatial mapping of molecular composition, resulting images are only a static snapshot in time of molecules involved in highly dynamic processes; kinetic information of flux through metabolic pathways is lacking. To address this limitation, we developed kinetic mass spectrometry imaging (kMSI), a novel technique integrating soft desorption/ionization mass spectrometry with clinically accepted in vivo metabolic labeling of tissue with deuterium to generate images of kinetic information of biological processes. Applied to a tumor, kMSI revealed heterogeneous spatial distributions of newly synthesized versus pre-existing lipids, with altered lipid synthesis patterns distinguishing region-specific intratumor subpopulations. Images also enabled identification and correlation of metabolic activity of specific lipids found in tumor regions of varying grade.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.