Evidence map›Paper›PMID 23584444›Full record

Trial reportBone marrow transplantation2013

Characteristics of chronic GVHD after cord blood transplantation.

L F Newell, M E D Flowers, T A Gooley, F Milano, P A Carpenter, P J Martin, C Delaney

Open access · greenAbstract readClinical Trial
In one paragraph

Trial report in Bone marrow transplantation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
  2. The Anatomic Distribution of Skin Involvement in Patients with Incident Chronic Graft-versus-Host Disease.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019
    Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Cord blood transplantation: rewind to fast forward.Bone marrow transplantation · 2017
    Review
  13. Article
  14. Article
  15. Risk Factors for Acute and Chronic Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation with Umbilical Cord Blood and Matched Sibling Donors.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2016
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

L F Newell1] Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA, USA [2] Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA [3] Division of Hematology and Medical Oncology, Department of Medicine, Oregon Health and Science University (OHSU) Knight Cancer Institute, Portland, OR, USA.
M E D Flowers
T A Gooley
F Milano
P A Carpenter
P J Martin
C Delaney
University of Washington · USFred Hutch Cancer Center · US

Funding

VIRUS-MEDIATED MYELOSUPPRESSIONP01CA018029 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STEPHANIE J LEE · 1985 to 2026
$128.4M
RESEARCH TRAINING IN HEMATOLOGYT32HL007093 · NHLBI · UNIVERSITY OF WASHINGTON · PI Janis L Abkowitz · 1985 to 2026
$13.9M
Notch Mediated Expansion of Hematopoietic PrecursorsR24HL074445 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BERNSTEIN, IRWIN D. · 2003 to 2007
$4.5M
Ex Vivo Expansion of Cord Blood Progenitor CellsK23HL077446 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DELANEY, COLLEEN · 2004 to 2008
$641k
NCI NIH HHS CA18029NCI NIH HHS P01 CA018029NHLBI NIH HHS K23 HL077446NHLBI NIH HHS R24 HL074445NHLBI NIH HHS R24 HL74445NHLBI NIH HHS T32 HL007093
6 · The paper itself

Abstract

Most reports of chronic GVHD after cord blood transplantation (CBT) have utilized traditional diagnostic criteria. We used traditional criteria and National Institutes of Health (NIH) criteria prospectively to evaluate chronic GVHD in a cohort of 87 adult and pediatric recipients of single or double unrelated CBT for treatment of hematologic malignancies. Fifty-four patients developed traditionally defined chronic GVHD, for an estimated 2-year probability of 64%. Among 54 patients, 25 (46%) met the NIH criteria for persistent, recurrent or late acute GVHD at onset. Twenty-four (44%) had overlap chronic GVHD, including one who presented initially with late acute GVHD, and only seven (13%) had classic chronic GVHD, including one who also presented initially with late acute GVHD. Among patients who successfully discontinued all systemic immunosuppression (SI), the median time to discontinuation of corticosteroid treatment was 315 days (range 28-977), and the median time to discontinuation of all SI was 353 days (range 67-977). Chronic GVHD diagnosed by traditional criteria after CBT had a predominance of acute GVHD clinical features.

Indexed as

AdolescentAdultAgedChildChild, PreschoolChronic DiseaseFemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansInfantInfant, NewbornMaleMiddle AgedProspective StudiesTransplantation Conditioning

Identifiers

PMID23584444
PMCPMC3795867
OpenAlexW2014503294

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.