ArticleBiosensors & bioelectronics2013
Sensing lectin-glycan interactions using lectin super-microarrays and glycans labeled with dye-doped silica nanoparticles.
Article in Biosensors & bioelectronics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Editors' Choice-Perspective-Deciphering the Glycan Kryptos by Solid-State Nanopore Single-Molecule Sensing: A Call for Integrated Advancements Across Glyco- and Nanopore Science.ECS sensors plus · 2024Article
- Glycopolymer-Wrapped Carbon Nanotubes Show Distinct Interaction of Carbohydrates With Lectins.Frontiers in chemistry · 2022Article
- Imaging, Identification and Inhibition of Microorganisms Using AIEgens.Topics in current chemistry (Cham) · 2021Review
- Analytical Methods for Characterization of Nanomaterial Surfaces.Analytical chemistry · 2021Review
- Recent Developments in the Use of Glyconanoparticles and Related Quantum Dots for the Detection of Lectins, Viruses, Bacteria and Cancer Cells.Frontiers in chemistry · 2021Review
- Quantification of binding affinity of glyconanomaterials with lectins.Chemical communications (Cambridge, England) · 2020Review
- The glyconanoparticle as carrier for drug delivery.Drug delivery · 2018Review
- Immobilization of glycans on solid surfaces for application in glycomics.Journal of carbohydrate chemistry · 2018Article
- Nanotechnology in Glycomics: Applications in Diagnostics, Therapy, Imaging, and Separation Processes.Medicinal research reviews · 2017Review
- Glyconanomaterials for biosensing applications.Biosensors & bioelectronics · 2016Review
- Aggregation-based detection of M. smegmatis using D-arabinose-functionalized fluorescent silica nanoparticles.Chemical communications (Cambridge, England) · 2015Article
- Selective targeting of Mycobacterium smegmatis with trehalose-functionalized nanoparticles.Chemical communications (Cambridge, England) · 2015Article
- Glyconanomaterials: Emerging applications in biomedical research.Nano research · 2014Article
- Classification of lectins by pattern recognition using glyconanoparticles.Analytical chemistry · 2013Article
- Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A new microarray platform, based on lectin super-microarrays and glycans labeled with dye-doped nanoparticles, has been developed to study glycan-lectin interactions. Glycan ligands were conjugated onto fluorescein-doped silica nanoparticles (FSNPs) using a general photocoupling chemistry to afford FSNP-labeled glycan probes. Lectins were printed on epoxy slides in duplicate sets to generate lectin super-microarrays where multiple assays could be carried out simultaneously in each lectin microarray. Thus, the lectin super-microarray was treated with FSNP-labeled glycans to screen for specific binding pairs. Furthermore, a series of ligand competition assays were carried out on a single lectin super-microarray to generate the dose-response curve for each glycan-lectin pair, from which the apparent affinity constants were obtained. Results showed 4-7 orders of magnitude increase in affinity over the free glycans with the corresponding lectins. Thus, the glycan epitope structures having weaker affinity than the parent glycans could be readily identified and analyzed from the lectin super-microarrays.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.