ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
Lithium, but not valproate, reduces impulsive choice in the delay-discounting task in mice.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Epidemiology, neurobiology and pharmacological interventions related to suicide deaths and suicide attempts in bipolar disorder: Part I of a report of the International Society for Bipolar Disorders Task Force on Suicide in Bipolar Disorder.The Australian and New Zealand journal of psychiatry · 2015Pooled it
- Lithium effects on impulsivity and emotional processing.Scientific reports · 2025Trial
- Adaptation of the 5-choice serial reaction time task to measure engagement and motivation for alcohol in mice.Frontiers in behavioral neuroscience · 2022Article
- Lithium in drinking water and crime rates in Japan: cross-sectional study.BJPsych open · 2020Article
- Diminished Myoinositol in Ventromedial Prefrontal Cortex Modulates the Endophenotype of Impulsivity.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Integrating Preclinical and Clinical Models of Negative Urgency.Frontiers in psychiatry · 2019Review
- Eradicating Suicide at Its Roots: Preclinical Bases and Clinical Evidence of the Efficacy of Ketamine in the Treatment of Suicidal Behaviors.International journal of molecular sciences · 2018Review
- Dissecting drug effects in preclinical models of impulsive choice: emphasis on glutamatergic compounds.Psychopharmacology · 2018Review
- Animal models to improve our understanding and treatment of suicidal behavior.Translational psychiatry · 2017Review
- Differential effects of cannabinoid CB1 inverse agonists and antagonists on impulsivity in male Sprague Dawley rats: identification of a possibly clinically relevant vulnerability involving the serotonin 5HTPsychopharmacology · 2017Article
- Chronic lithium treatment rectifies maladaptive dopamine release in the nucleus accumbens.Journal of neurochemistry · 2016Article
- Acute administration of lithium, but not valproate, modulates cognitive judgment bias in rats.Psychopharmacology · 2015Article
- Inflammation and lithium: clues to mechanisms contributing to suicide-linked traits.Translational psychiatry · 2014Review
- The treatment of bipolar patients with elevated impulsivity and suicide risk.Journal of psychiatry & neuroscience : JPN · 2014Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Both lithium and valproate are well-established treatments for bipolar disorder. Studies have also found that lithium is effective at reducing suicidal behaviors in patients with mood disorders. Impulsivity is a validated endophenotype of both bipolar disorder and suicidal behavior. We assessed effects of treatment with lithium or valproate on cognitive impulsivity in selectively bred mice previously shown to manifest relatively high levels of cognitive impulsivity. Mice were trained in the delay-discounting paradigm, a measure of cognitive impulsivity reflecting a behavioral bias towards immediacy, and then treated with lithium, valproate, or control chow. After 3 weeks of drug treatment, mice were tested at various delays to a large, delayed reward. Drug treatment continued during this time. Lithium reduced impulsivity, whereas valproate had no effect on choice behavior. Both drugs increased the number of choice trials and reinforcer intake, but effects on choice behavior did not depend on these motivational changes. To our knowledge, this is the first study demonstrating lithium's effects to reduce cognitive impulsivity. Future studies may focus on the ability of putative pharmacotherapies for patients at risk for bipolar disorder or suicide to modify the impulsive choice dimension of this diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.