ArticleJournal of neuropathology and experimental neurology2013
Synaptic changes in the dentate gyrus of APP/PS1 transgenic mice revealed by electron microscopy.
Article in Journal of neuropathology and experimental neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- GABAeNeuro · 2026Article
- Direct evidence for dendritic spine compensation and regeneration in Alzheimer's disease models.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer's disease models.Translational neurodegeneration · 2024Article
- The Role of the Complement System in Synaptic Pruning after Stroke.Aging and disease · 2024Review
- NAMPT‑NADExperimental and therapeutic medicine · 2024Article
- Synaptic Compensatory Plasticity in Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Focused ultrasound with anti-pGlu3 Aβ enhances efficacy in Alzheimer's disease-like mice via recruitment of peripheral immune cells.Journal of controlled release : official journal of the Controlled Release Society · 2021Article
- Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer's disease mouse model.Communications biology · 2021Article
- The Density of Group I mGluInternational journal of molecular sciences · 2021Article
- Three-dimensional analysis of synaptic organization in the hippocampal CA1 field in Alzheimer's disease.Brain : a journal of neurology · 2021Article
- Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin.eLife · 2020Article
- PhIP exposure in rodents produces neuropathology potentially relevant to Alzheimer's disease.Toxicology · 2020Article
- Reduction in the neuronal surface of post and presynaptic GABABrain pathology (Zurich, Switzerland) · 2020Article
- Density of GABAInternational journal of molecular sciences · 2020Article
- Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model.Molecular neurodegeneration · 2020Article
- Age-Dependent Shift of AMPA Receptors From Synapses to Intracellular Compartments in Alzheimer's Disease: Immunocytochemical Analysis of the CA1 Hippocampal Region in APP/PS1 Transgenic Mouse Model.Frontiers in aging neuroscience · 2020Article
- Distinguishing normal brain aging from the development of Alzheimer's disease: inflammation, insulin signaling and cognition.Neural regeneration research · 2018Review
- Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer's disease patients.Acta neuropathologica communications · 2018Article
- Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice.Science translational medicine · 2017Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous studies have reported widespread synaptic dysfunction or loss in early stages of both Alzheimer disease (AD) patients and animal models; it is widely accepted that synapse loss is the major structural correlate of cognitive dysfunction. Elucidation of the changes that may affect synapses is crucial for understanding the pathogenic mechanisms underlying AD, but ultrastructural preservation of human postmortem brain tissue is often poor, and classical methods for quantification of synapses have significant technical limitations. We previously observed changes in dendritic spines in plaque-free regions of the neuropil of the dentate gyrus of double-transgenic APP/PS1 (amyloid precursor protein/presenilin 1) model mice by light microscopy. Here, we used electron microscopy to examine possible synaptic alterations in this region. We used standard stereologic techniques to determine numbers of synapses per volume. We were able to reconstruct and analyze thousands of synapses and their 3-dimensional characteristics using a focused ion beam/scanning electron microscope and 3-dimensional reconstruction software (EspINA), which performs semiautomated segmentation of synapses. Our results show that both numbers of synapses per volume and synaptic morphology are affected in plaque-free regions of APP/PS1 mice. Therefore, changes in the number and morphology of synapses seem to be widespread alterations in this animal model.
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