ArticleRNA biology2013
Novel insights into gene regulation of the rudivirus SIRV2 infecting Sulfolobus cells.
Article in RNA biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- The infection cycle of the haloarchaeal virus HFTV1 is tightly regulated and strongly inhibits motility of its host.mSystems · 2025Article
- Virocell resource manipulation under nutrient limitation.mSystems · 2025Article
- In Silico Approaches for Prediction of Anti-CRISPR Proteins.Journal of molecular biology · 2023Review
- A clade of RHH proteins ubiquitous in Sulfolobales and their viruses regulates cell cycle progression.Nucleic acids research · 2023Article
- Sulfolobus islandicus Employs Orc1-2-Mediated DNA Damage Response in Defense against Infection by SSV2.Journal of virology · 2022Article
- Isolation of a virus causing a chronic infection in the archaeal model organismProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Characterization of Blf4, an Archaeal Lytic Virus Targeting a Member of the Methanomicrobiales.Viruses · 2021Article
- Insights into gene regulation of the halovirus His2 infecting Haloarcula hispanica.MicrobiologyOpen · 2020Article
- Stable maintenance of the rudivirus SIRV3 in a carrier state in Sulfolobus islandicus despite activation of the CRISPR-Cas immune response by a second virus SMV1.RNA biology · 2019Article
- Anti-CRISPR-Based and CRISPR-Based Genome Editing ofViruses · 2018Article
- Anti-CRISPR proteins encoded by archaeal lytic viruses inhibit subtype I-D immunity.Nature microbiology · 2018Article
- Viruses of archaea: Structural, functional, environmental and evolutionary genomics.Virus research · 2018Review
- Methanosarcina Spherical Virus, a Novel Archaeal Lytic Virus Targeting Methanosarcina Strains.Journal of virology · 2017Article
- Interaction of extremophilic archaeal viruses with human and mouse complement system and viral biodistribution in mice.Molecular immunology · 2017Article
- Article
- Formation of a Viral Replication Focus in Sulfolobus Cells Infected by the Rudivirus Sulfolobus islandicus Rod-Shaped Virus 2.Journal of virology · 2017Article
- A type III-B CRISPR-Cas effector complex mediating massive target DNA destruction.Nucleic acids research · 2017Article
- CRISPR-Cas type I-A Cascade complex couples viral infection surveillance to host transcriptional regulation in the dependence of Csa3b.Nucleic acids research · 2017Article
- Recognition of extremophilic archaeal viruses by eukaryotic cells: a promising nanoplatform from the third domain of life.Scientific reports · 2016Article
- Multiple consecutive initiation of replication producing novel brush-like intermediates at the termini of linear viral dsDNA genomes with hairpin ends.Nucleic acids research · 2016Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microarray analysis of infection by a lytic Sulfolobus rudivirus, SIRV2, revealed both the temporal expression of viral genes and the differential regulation of host genes. A highly susceptible strain derived from Sulfolobus solfataricus P2 with a large genomic deletion spanning CRISPR clusters A to D was infected with SIRV2, and subjected to a microarray analysis. Transcripts from a few viral genes were detected at 15 min post-infection and all except one were expressed within 2 h. The earliest expressed genes were located mainly at the termini of the linear viral genome while later expressed genes were concentrated in the central region. Timing of the expression correlated with the known or predicted functions of the viral gene products and, thus, should facilitate functional characterization of many hypothetical viral genes. Evaluation of the microarray data with quantitative reverse-transcription PCR analyses of a few selected viral genes revealed a good correlation between the two methods. Expression of about 3,000 host genes was examined. Seventy-two were downregulated>2-fold that were mainly associated with stress response and vesicle formation, as well as chromosome structure maintenance, which appears to contribute to host chromosome degradation and cellular collapse. A further 76 host genes were upregulated>2-fold and they were dominated by genes associated with metabolism and membrane transport, including phosphate transport and DNA precursor synthesis. The altered transcriptional patterns suggest that the virus reprograms the host cellular machinery to facilitate its own DNA replication and to inhibit cellular processes required for defense against viruses.
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