Evidence map›Paper›PMID 23584084›Full record

ReviewNutrients2013

Dyslipidemia in obesity: mechanisms and potential targets.

Boudewijn Klop, Jan Willem F Elte, Manuel Castro Cabezas

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04894318 (The Short Term Beneficıal Effects Of A Low-Fat And Low-Cholesterol Dietary Intervention On LDL Sub-Groups In Dyslipidemic Turkish Patients), which is not on this map. Cited by 746 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
746citing papers in PubMed, 5 pooled it
44.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04894318 nacompletednot on this mapstarted 2017, after this paper: background citation

The Short Term Beneficıal Effects Of A Low-Fat And Low-Cholesterol Dietary Intervention On LDL Sub-Groups In Dyslipidemic Turkish Patients

TypeinterventionalSponsorTC Erciyes UniversityRan2017 to 2019Enrolled47ConditionsDyslipidemiasArmsLow-fat and low-cholesterol diet
3 · Its place in the literature

Who cites it

746 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,637 citations in OpenAlex.

  1. Pooled it
  2. Cryolipolysis and associated health outcomes, adverse events, and satisfaction: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Pooled it
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  13. Review
  14. Features of Lipid Disorders in Cardiovascular-Kidney-Metabolic Syndrome.International journal of molecular sciences · 2026
    Review
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686 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Boudewijn KlopDepartment of Internal Medicine, Diabetes and Vascular Centre, Sint Franciscus Gasthuis, Rotterdam, P.O. Box 10900, 3004 BA, The Netherlands. m.castrocabezas@sfg.nl
Jan Willem F Elte
Manuel Castro Cabezas
Sint Franciscus Gasthuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity has become a major worldwide health problem. In every single country in the world, the incidence of obesity is rising continuously and therefore, the associated morbidity, mortality and both medical and economical costs are expected to increase as well. The majority of these complications are related to co-morbid conditions that include coronary artery disease, hypertension, type 2 diabetes mellitus, respiratory disorders and dyslipidemia. Obesity increases cardiovascular risk through risk factors such as increased fasting plasma triglycerides, high LDL cholesterol, low HDL cholesterol, elevated blood glucose and insulin levels and high blood pressure. Novel lipid dependent, metabolic risk factors associated to obesity are the presence of the small dense LDL phenotype, postprandial hyperlipidemia with accumulation of atherogenic remnants and hepatic overproduction of apoB containing lipoproteins. All these lipid abnormalities are typical features of the metabolic syndrome and may be associated to a pro-inflammatory gradient which in part may originate in the adipose tissue itself and directly affect the endothelium. An important link between obesity, the metabolic syndrome and dyslipidemia, seems to be the development of insulin resistance in peripheral tissues leading to an enhanced hepatic flux of fatty acids from dietary sources, intravascular lipolysis and from adipose tissue resistant to the antilipolytic effects of insulin. The current review will focus on these aspects of lipid metabolism in obesity and potential interventions to treat the obesity related dyslipidemia.

Indexed as

Caloric RestrictionRisk Reduction BehaviorBiomarkersComorbidityDyslipidemiasHumansHypolipidemic AgentsInflammation MediatorsInsulin ResistanceLipid MetabolismLipidsObesityRisk FactorsTreatment OutcomeBiomarkersHypolipidemic AgentsInflammation MediatorsLipids

Identifiers

PMID23584084
PMCPMC3705344
OpenAlexW1985399572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.