ReviewAlcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism2010
Focus on the brain: HIV infection and alcoholism: comorbidity effects on brain structure and function.
Review in Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 39 citations in OpenAlex.
- Alcohol Use and Its Associations With Frailty, Fractures, and Falls Among Older Adults With HIV.Alcohol research : current reviews · 2025Review
- Frontal cortical volume deficits as enduring evidence of childhood abuse in community adults with AUD and HIV infection comorbidity.Neurobiology of stress · 2024Article
- Cocaine regulates antiretroviral therapy CNS access through pregnane-x receptor-mediated drug transporter and metabolizing enzyme modulation at the blood brain barrier.Fluids and barriers of the CNS · 2024Article
- Mapping Studies of Alcohol Use Among People Living with HIV/AIDS During 1990-2019 (GAPRESEARCH).AIDS and behavior · 2023Review
- Living with HIV and Getting Vaccinated: A Narrative Review.Vaccines · 2023Review
- Resting state connectivity in people living with HIV before and after stopping heavy drinking.Frontiers in psychiatry · 2023Article
- Alcohol Use Disorder and Its Comorbidity With HIV Infection Disrupts Anterior Cingulate Cortex Functional Connectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Self-Management Frameworks for Youth Living with Human Immunodeficiency Virus.Pediatric clinics of North America · 2022Review
- Binge Drinking Relates to Worse Neurocognitive Functioning Among Adults Aging with HIV.Journal of the International Neuropsychological Society : JINS · 2022Article
- Alcohol Enhances Responses to High Frequency Stimulation in Hippocampus from Transgenic Mice with Increased Astrocyte Expression of IL-6.Cellular and molecular neurobiology · 2021Article
- The Effects of Low-Risk Drinking on Neurocognition Among Older Persons Living With HIV as Compared to Those Without HIV.Alcoholism, clinical and experimental research · 2020Article
- Genetic variation in alcohol dehydrogenase is associated with neurocognition in men with HIV and history of alcohol use disorder: preliminary findings.Journal of neurovirology · 2020Article
- Data-Driven Exploration of Brain Structure Using Statistical Machine Learning: Validity of Derived Diagnostic Patterns in Alcohol Use Disorder and Human Immunodeficiency Virus Infection.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Age of Last Alcohol Use Disorder Relates to Processing Speed Among Older Adults Living with HIV.Alcohol and alcoholism (Oxford, Oxfordshire) · 2019Article
- Antiretroviral drug-S for a possible HIV elimination.International journal of physiology, pathophysiology and pharmacology · 2019Article
- Heavy Alcohol Use and Age Effects on HIV-Associated Neurocognitive Function.Alcoholism, clinical and experimental research · 2019Article
- Inter-trial variability in brain activity as an indicator of synergistic effects of HIV-1 and drug abuse.Drug and alcohol dependence · 2018Article
- The Impact of Alcohol Use on Frontal White Matter in HIV.Alcoholism, clinical and experimental research · 2018Article
- Impact of Alcohol on HIV Disease Pathogenesis, Comorbidities and Aging: Integrating Preclinical and Clinical Findings.Alcohol and alcoholism (Oxford, Oxfordshire) · 2018Review
- The Aging Brain With HIV Infection: Effects of Alcoholism or Hepatitis C Comorbidity.Frontiers in aging neuroscience · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Both HIV infection and alcohol abuse have negative effects on the brain, with some unique to each condition and others shared by both conditions. Investigators have used magnetic resonance imaging to study the size and integrity of various brain structures in participants with alcoholism, HIV infection, or both conditions and in healthy control subjects. In these studies, alcoholics exhibited enlarged, cerebrospinal fluid-filled spaces (i.e., ventricles) as well as tissue shrinkage in various brain regions (e.g., the corpus callosum and frontal cortex), whereas study participants with asymptomatic HIV infection showed few abnormalities. Those with both HIV infection and alcoholism also had these volume abnormalities, particularly if they had experienced an AIDS-defining event. Diffusion tensor imaging, which measures the integrity of white matter fibers, has identified abnormalities of constituents of these fibers in both diseases. Again, people with HIV infection plus alcoholism show the greatest abnormalities, particularly those with a history of an AIDS-defining event. Magnetic resonance spectroscopy, which assesses the levels of brain metabolites and selective neurotransmitters, has revealed different patterns of deficits in biochemical markers of brain integrity in individuals singly affected and a compounding of effects in individuals with both HIV infection and alcoholism. Finally, neuropsychological studies have revealed impairment in selective functions involving working memory, visuospatial abilities, and movement speed that are especially likely to occur in people with comorbid HIV infection and alcoholism. Thus, alcoholism is a major risk factor for development of neuropathology and its functional sequelae in HIV-infected people.
Indexed as
Identifiers
23584066PMC3860510W2138204804What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.