ReviewAlcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism2008
The molecular basis of tolerance.
Review in Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- AlteredeNeuro · 2026Article
- Interpretive Reference Ranges for Plasma Drug Concentrations in Acute Recreational Drug Toxicity: A Short Communication.Therapeutic drug monitoring · 2026Review
- Disruption of Dopamine Homeostasis by Psychostimulants.Molecular neurobiology · 2026Review
- AlteredbioRxiv : the preprint server for biology · 2025Article
- Effects of Ethanol and Opioid Receptor Antagonists Naltrexone and LY2444296 on the Organization of Cholesterol- and Sphingomyelin-Enriched Plasma Membrane Domains.ACS chemical neuroscience · 2025Article
- Memory-like states created by the first ethanol experience are encoded into the Drosophila mushroom body learning and memory circuitry in an ethanol-specific manner.PLoS genetics · 2025Article
- Molecular and cellular basis of mu-opioid receptor signaling: mechanisms underlying tolerance and dependence development.Frontiers in neuroscience · 2025Review
- Understanding How Acute Alcohol Impacts Neural Encoding in the Rodent Brain.Current topics in behavioral neurosciences · 2025Review
- Clinicopathological Characteristics of Lichenoid Drug Eruption: A 17-Year Retrospective Study.Clinical, cosmetic and investigational dermatology · 2025Article
- Proton motive force and antibiotic tolerance in bacteria.Microbial biotechnology · 2024Review
- Concentration- and time-dependent behavioural effects of ethanol on Lumbriculus variegatus.Genes, brain, and behavior · 2024Article
- Does tolerance to ethanol-induced ataxia explain the sensitized response to ethanol?Frontiers in psychiatry · 2024Article
- The Stage-Based Model of Addiction-UsingInternational journal of molecular sciences · 2023Review
- Optimized Administration of the MACS chemical neuroscience · 2022Article
- Tolerance to alcohol: A critical yet understudied factor in alcohol addiction.Pharmacology, biochemistry, and behavior · 2021Review
- Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs.Frontiers in molecular neuroscience · 2021Review
- Apremilast regulates acute effects of ethanol and other GABAergic drugs via protein kinase A-dependent signaling.Neuropharmacology · 2020Article
- Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity.Nucleic acids research · 2020Article
- Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1.Scientific reports · 2020Article
- Time-Dependent Effects of Ethanol on BK Channel Expression and Trafficking in Hippocampal Neurons.Alcoholism, clinical and experimental research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tolerance is defined as the diminished response to alcohol or other drugs over the course of repeated or prolonged exposure. This mechanism allows physiological processes to achieve stability in a constantly changing environment. The onset of tolerance may occur within minutes, during a single exposure to alcohol (i.e., acute tolerance), or over longer timeframes and with prolonged exposure to alcohol (i.e., rapid or chronic tolerance). Changes in tolerance induced by alcohol may affect several processes at the molecular, cellular, or behavioral level. These effects often are interrelated and may be difficult to separate. This article describes changes at the molecular level that are related to the onset of acute, rapid, or chronic tolerance. It focuses on neuronal membrane-bound channels and the factors that affect their function and production, such as modification of protein synthesis and activity, interaction with the membrane lipid microenvironment, epigenetic effects on cytoplasmic regulation, and gene transcription. Also considered is the genetics of tolerance.
Indexed as
Identifiers
23584007PMC3860466What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.