SynthesisNature genetics2013
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers, 11 of them syntheses that pooled it.
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165citing papers in PubMed, 11 pooled it
–field-weighted citation impact
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
165 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- A meta-analysis and polygenic score study identifies novel genetic markers for waist-hip ratio in African populations.Obesity (Silver Spring, Md.) · 2024Pooled it
- GWAS-Identified Variants for Obesity Do Not Influence the Risk of Developing Multiple Myeloma: A Population-Based Study and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI.International journal of obesity (2005) · 2018Pooled it
- Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.Nature communications · 2017Pooled it
- Pooled it
- Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.American journal of human genetics · 2016Pooled it
- New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.Nature communications · 2016Pooled it
- Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals.Human molecular genetics · 2015Pooled it
- Genetic studies of body mass index yield new insights for obesity biology.Nature · 2015 · on this mapPooled it
- A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS).PloS one · 2015Pooled it
- Meta-analyses between 18 candidate genetic markers and overweight/obesity.Diagnostic pathology · 2014Pooled it
- Peer influence on obesity: Evidence from a natural experiment of a gene-environment interaction.Social science research · 2021Trial
- Interaction between anNutrients · 2018Trial
- Identifying sex-specific genetic effects across 733 traits in UK biobank.BMC genomics · 2026Article
- Obesity genetic association prospective cohort utilizing single center real-world evidence data.Medicine · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- TheLife metabolism · 2024Article
- Identification of novel genes whose expression in adipose tissue affects body fat mass and distribution: an RNA-Seq and Mendelian Randomization study.European journal of human genetics : EJHG · 2024Article
- Relation Between Obesity and Type 2 Diabetes: Evolutionary Insights, Perspectives and Controversies.Current obesity reports · 2024Review
- Article
105 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
212 authors.
Keri L MondaThe Center for Observational Research, Amgen, Inc. Thousand Oaks, California, USA.
Gary K Chen
Kira C Taylor
Cameron Palmer
Todd L Edwards
Leslie A Lange
Maggie C Y Ng
Adebowale A Adeyemo
Matthew A Allison
Lawrence F Bielak
Guanjie Chen
Mariaelisa Graff
Marguerite R Irvin
Suhn K Rhie
Guo Li
Yongmei Liu
Youfang Liu
Yingchang Lu
Michael A Nalls
Yan V Sun
Mary K Wojczynski
Lisa R Yanek
Melinda C Aldrich
Adeyinka Ademola
Christopher I Amos
Elisa V Bandera
Cathryn H Bock
Angela Britton
Ulrich Broeckel
Quiyin Cai
Neil E Caporaso
Chris S Carlson
John Carpten
Graham Casey
Wei-Min Chen
Fang Chen
Yii-Der I Chen
Charleston W K Chiang
Gerhard A Coetzee
Ellen Demerath
Sandra L Deming-Halverson
Ryan W Driver
Patricia Dubbert
Mary F Feitosa
Ye Feng
Barry I Freedman
Elizabeth M Gillanders
Omri Gottesman
Xiuqing Guo
Talin Haritunians
Tamara Harris
Curtis C Harris
Anselm J M Hennis
Dena G Hernandez
Lorna H McNeill
Timothy D Howard
Barbara V Howard
Virginia J Howard
Karen C Johnson
Sun J Kang
Brendan J Keating
Suzanne Kolb
Lewis H Kuller
Abdullah Kutlar
Carl D Langefeld
Guillaume Lettre
Kurt Lohman
Vaneet Lotay
Helen Lyon
Joann E Manson
William Maixner
Yan A Meng
Kristine R Monroe
Imran Morhason-Bello
Adam B Murphy
Josyf C Mychaleckyj
Rajiv Nadukuru
Katherine L Nathanson
Uma Nayak
Amidou N'diaye
Barbara Nemesure
Suh-Yuh Wu
M Cristina Leske
Christine Neslund-Dudas
Marian Neuhouser
Sarah Nyante
Heather Ochs-Balcom
Adesola Ogunniyi
Temidayo O Ogundiran
Oladosu Ojengbede
Olufunmilayo I Olopade
Julie R Palmer
Edward A Ruiz-Narvaez
Nicholette D Palmer
Michael F Press
Evandine Rampersaud
Laura J Rasmussen-Torvik
Jorge L Rodriguez-Gil
Babatunde Salako
Eric E Schadt
Ann G Schwartz
Daniel A Shriner
David Siscovick
Shad B Smith
Sylvia Wassertheil-Smoller
Elizabeth K Speliotes
Margaret R Spitz
Lara Sucheston
Herman Taylor
Bamidele O Tayo
Margaret A Tucker
David J Van Den Berg
Digna R Velez Edwards
Zhaoming Wang
John K Wiencke
Thomas W Winkler
John S Witte
Margaret Wrensch
Xifeng Wu
James J Yang
Albert M Levin
Taylor R Young
Neil A Zakai
Mary Cushman
Krista A Zanetti
Jing Hua Zhao
Wei Zhao
Yonglan Zheng
Jie Zhou
Regina G Ziegler
Joseph M Zmuda
Jyotika K Fernandes
Gary S Gilkeson
Diane L Kamen
Kelly J Hunt
Ida J Spruill
Christine B Ambrosone
Stefan Ambs
Donna K Arnett
Larry Atwood
Diane M Becker
Sonja I Berndt
Leslie Bernstein
William J Blot
Ingrid B Borecki
Erwin P Bottinger
Donald W Bowden
Gregory Burke
Stephen J Chanock
Richard S Cooper
Jingzhong Ding
David Duggan
Michele K Evans
Caroline Fox
W Timothy Garvey
Jonathan P Bradfield
Hakon Hakonarson
Struan F A Grant
Ann Hsing
Lisa Chu
Jennifer J Hu
Dezheng Huo
Sue A Ingles
Esther M John
Joanne M Jordan
Edmond K Kabagambe
Sharon L R Kardia
Rick A Kittles
Phyllis J Goodman
Eric A Klein
Laurence N Kolonel
Loic Le Marchand
Simin Liu
Barbara McKnight
Robert C Millikan
Thomas H Mosley
Badri Padhukasahasram
L Keoki Williams
Sanjay R Patel
Ulrike Peters
Curtis A Pettaway
Patricia A Peyser
Bruce M Psaty
Susan Redline
Charles N Rotimi
Benjamin A Rybicki
Michèle M Sale
Pamela J Schreiner
Lisa B Signorello
Andrew B Singleton
Janet L Stanford
Sara S Strom
Michael J Thun
Mara Vitolins
Wei Zheng
Jason H Moore
Scott M Williams
Shamika Ketkar
Xiaofeng Zhu
Alan B Zonderman
NABEC Consortium
UKBEC Consortium
BioBank Japan Project
AGEN Consortium
Charles Kooperberg
George J Papanicolaou
Brian E Henderson
Alex P Reiner
Joel N Hirschhorn
Ruth J F Loos
Kari E North
Christopher A Haiman
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MSWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2MVirology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5MTumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8MTumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9MVCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MSouthern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0MTissue Procurement & PathologyP50CA058223 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHARLES M PEROU · 1992 to 2026
$59.3MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MGenetic epidemiology of complex diseasesZIAHG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2009 to 2025
$54.7MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0MIntramural NIH HHS Z01 HG200362NCATS NIH HHS KL2 TR000446NCATS NIH HHS UL1 TR000055NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCATS NIH HHS UL1 TR000150NCATS NIH HHS UL1 TR000439NCI NIH HHS CA056678NCI NIH HHS CA082664NCI NIH HHS CA092447NCI NIH HHS CA092579NCI NIH HHS CA100374NCI NIH HHS CA127298NCI NIH HHS CA1326792NCI NIH HHS CA140388NCI NIH HHS CA148085NCI NIH HHS CA164973NCI NIH HHS CA54281NCI NIH HHS CA58223NCI NIH HHS CA63464NCI NIH HHS CA68485NCI NIH HHS CA68578NCI NIH HHS CA73629NCI NIH HHS CA77305NCI NIH HHS CA88164NCI NIH HHS K07 CA136969NCI NIH HHS P30 CA016086NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA060553NCI NIH HHS P50 CA058223NCI NIH HHS P50 CA125183NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA055769NCI NIH HHS R01 CA056678NCI NIH HHS R01 CA058420NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA073629NCI NIH HHS R01 CA077305NCI NIH HHS R01 CA082664NCI NIH HHS R01 CA088164NCI NIH HHS R01 CA089085NCI NIH HHS R01 CA092447NCI NIH HHS R01 CA092579NCI NIH HHS R01 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Abstract
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10(-11)) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10(-10)). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10(-8)). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.
Indexed as
Body Mass IndexBlack or African AmericanCase-Control StudiesGene FrequencyGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLinkage DisequilibriumObesityPolymorphism, Single Nucleotide
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