ArticleNeurotoxicology2013
Dietary nimodipine delays the onset of methylmercury neurotoxicity in mice.
Article in Neurotoxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Oral nimodipine treatment has no effect on amyloid pathology or neuritic dystrophy in the 5XFAD mouse model of amyloidosis.PloS one · 2022Article
- Nimodipine promotes neurite outgrowth and protects against neurotoxicity in PC12 cells.Iranian journal of basic medical sciences · 2021Article
- d-Amphetamine and methylmercury exposure during adolescence alters sensitivity to monoamine uptake inhibitors in adult mice.Neurotoxicology · 2019Article
- Evaluating a Gene-Environment Interaction in Amyotrophic Lateral Sclerosis: Methylmercury Exposure and Mutated SOD1.Current environmental health reports · 2017Review
- Effects of methylmercury on spinal cord afferents and efferents-A review.Neurotoxicology · 2017Review
- The catecholaminergic neurotransmitter system in methylmercury-induced neurotoxicity.Advances in neurotoxicology · 2017Article
- Protective effects of nimodipine and lithium against aluminum-induced cell death and oxidative stress in PC12 cells.Iranian journal of basic medical sciences · 2016Article
- A bout analysis reveals age-related methylmercury neurotoxicity and nimodipine neuroprotection.Behavioural brain research · 2016Article
- Examination of clozapine and haloperidol in improving ketamine-induced deficits in an incremental repeated acquisition procedure in BALB/c mice.Psychopharmacology · 2016Article
- Spatial discrimination reversal and incremental repeated acquisition in adolescent and adult BALB/c mice.Behavioural processes · 2015Article
- Neuroprotective and neuroregenerative effects of nimodipine in a model system of neuronal differentiation and neurite outgrowth.Molecules (Basel, Switzerland) · 2015Article
- Inhibition of voltage-gated calcium channels as common mode of action for (mixtures of) distinct classes of insecticides.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Adult-onset methylmercury (MeHg) exposure is thought to result primarily in sensory and motor deficits but effects on learning are poorly understood. One mechanism by which chronic MeHg may exert its neurotoxicity is via sustained disruption of intracellular calcium homeostasis, with a consequent increase of intracellular Ca(2+) ions in vulnerable neurons. A biochemically heterogeneous group of compounds, calcium channel blockers, have been shown in vitro to attenuate MeHg's toxicity. To evaluate the role of calcium antagonism in MeHg toxicity in vivo, adult BALB/c mice were exposed chronically to 0 or 15 ppm of Hg (as MeHg) via drinking water and to nimodipine, a dihydropryidine, L-type Ca(2+) channel blocker with action in the CNS. Nimodipine was administered orally in diets (0, 20, or 200 ppm, producing approximately 0, 2, or 20 mg/kg/day of nimodipine). An incremental repeated acquisition (IRA) of response chains procedure was used to detect MeHg-induced deficits in learning or motoric function and to evaluate possible neuroprotection by nimodipine. MeHg impaired performance on the IRA task, and this was partially or completely blocked by dietary nimodipine, depending on dose. Measures of learning co-varied with measures of motoric function as indicated by overall response rate. Nimodipine delayed or prevented the behavioral toxicity of MeHg exposure as evidenced by IRA performance; effects on learning seemed secondary to response rate decreases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.