ArticleFEBS letters2013
Levels of supramolecular chirality of polyglutamine aggregates revealed by vibrational circular dichroism.
Article in FEBS letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Structural Insights Into Amyloid Polymorphism: The Impact of Glutamine to Norleucine Substitutions in GNNQQNY Aggregation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Article
- Protofilament Structure and Supramolecular Polymorphism of Aggregated Mutant Huntingtin Exon 1.Journal of molecular biology · 2020Article
- Article
- Understanding amyloid fibril formation using protein fragments: structural investigations via vibrational spectroscopy and solid-state NMR.Biophysical reviews · 2018Review
- Advances of Vibrational Circular Dichroism (VCD) in bioanalytical chemistry. A review.Analytica chimica acta · 2017Review
- Spatially resolved spectroscopic differentiation of hydrophilic and hydrophobic domains on individual insulin amyloid fibrils.Scientific reports · 2016Article
- Inversion of Supramolecular Chirality by Sonication-Induced Organogelation.Scientific reports · 2015Article
- Molecular interaction between the chaperone Hsc70 and the N-terminal flank of huntingtin exon 1 modulates aggregation.The Journal of biological chemistry · 2015Article
- Biophysical underpinnings of the repeat length dependence of polyglutamine amyloid formation.The Journal of biological chemistry · 2014Article
- Is supramolecular filament chirality the underlying cause of major morphology differences in amyloid fibrils?Journal of the American Chemical Society · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Polyglutamine (PolyQ) aggregates are a hallmark of several severe neurodegenerative diseases, expanded CAG-repeat diseases in which inheritance of an expanded polyQ sequence above a pathological threshold is associated with a high risk of disease. Application of vibrational circular dichroism (VCD) reveals that these PolyQ fibril aggregates exhibit a chiral supramolecular organization that is distinct from the supramolecular organization of previously observed amyloid fibrils. PolyQ fibrils grown from monomers with Q repeats 35 and above (Q≥35) exhibit approximately 10-fold enhancement of the same VCD spectrum compared to the already enhanced VCD of fibrils formed from Q repeats 30 and below (Q≤30).
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