ArticleDevelopmental biology2013
Socs36E attenuates STAT signaling to optimize motile cell specification in the Drosophila ovary.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Live imaging of delamination in Drosophila shows epithelial cell motility and invasiveness are independently regulated.Scientific reports · 2022Article
- Spatiotemporal gating of Stat nuclear influx byScience advances · 2022Article
- Border cell polarity and collective migration require the spliceosome component Cactin.The Journal of cell biology · 2022Article
- E-cadherin acts as a positive regulator of the JAK-STAT signaling pathway duringFrontiers in cell and developmental biology · 2022Article
- Article
- Signal transducer and activator of transcription (STAT) 1 and STAT3 are expressed in the human ovary and have Janus kinase 1-independent functions in the COV434 human granulosa cell line.Reproduction, fertility, and development · 2020Article
- Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis.International journal of molecular sciences · 2018Review
- TheDevelopment (Cambridge, England) · 2018Article
- LncRNA mediated regulation of aging pathways inAging · 2016Article
- Identification of Novel Regulators of the JAK/STAT Signaling Pathway that Control Border Cell Migration in the Drosophila Ovary.G3 (Bethesda, Md.) · 2016Article
- Apontic regulates somatic stem cell numbers in Drosophila testes.BMC developmental biology · 2016Article
- Tousled-like kinase regulates cytokine-mediated communication between cooperating cell types during collective border cell migration.Molecular biology of the cell · 2016Article
- Tissue landscape alters adjacent cell fates during Drosophila egg development.Nature communications · 2015Article
- A mathematical model of collective cell migration in a three-dimensional, heterogeneous environment.PloS one · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Janus kinase/Signal transducers and activators of transcription (JAK/STAT) pathway determines cell fates by regulating gene expression. One example is the specification of the motile cells called border cells during Drosophila oogenesis. It has been established that too much or too little STAT activity disrupts follicle cell identity and cell motility, which suggests the signaling must be precisely regulated. Here, we find that Suppressor of cytokine signaling at 36E (Socs36E) is a necessary negative regulator of JAK/STAT signaling during border cell specification. We find when STAT signaling is too low to induce migration in the presumptive border cell population, nearby follicle cells uncharacteristically become invasive to enable efficient migration of the cluster. We generated a genetic null allele that reveals Socs36E is required in the anterior follicle cells to limit invasive behavior to an optimal number of cells. We further show Socs36E genetically interacts with the required STAT feedback inhibitor apontic (apt) and APT's downstream target, mir-279, and provide evidence that suggests APT directly regulates Socs36E transcriptionally. Our work shows Socs36E plays a critical role in a genetic circuit that establishes a boundary between the motile border cell cluster and its non-invasive epithelial neighbors through STAT attenuation.
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