Evidence map›Paper›PMID 23583578›Full record

ReviewTrends in cell biology2013

Postage for the messenger: designating routes for nuclear mRNA export.

Barbara J Natalizio, Susan R Wente

Abstract readReview
In one paragraph

Review in Trends in cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed.

  1. Article
  2. Article
  3. RNA-Binding Proteins: Modulators of Canonical Wnt Signaling Pathway.International journal of molecular sciences · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Virus Infection and mRNA Nuclear Export.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Review
  13. Review
  14. Cancer cells hijack RNA processing to rewrite the message.Biochemical Society transactions · 2022
    Article
  15. Article
  16. Review
  17. Advances in mRNA vaccines.International review of cell and molecular biology · 2022
    Review
  18. Review
  19. Article
  20. The Great Escape: mRNA Export through the Nuclear Pore Complex.International journal of molecular sciences · 2021
    Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Barbara J NatalizioDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37323, USA.
Susan R Wente

Funding

Integrated Biological Systems Training in OncologyT32CA119925 · NCI · VANDERBILT UNIVERSITY · PI Vivian Gama, William Patrick Tansey · 2008 to 2026
$7.6M
New Tools for Exploring the Dynamic Interactome (Renewal)U54GM103511 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2012 to 2013
$6.2M
Molecular Analysis of Nuclear Pore Complex FunctionR37GM051219 · NIGMS · VANDERBILT UNIVERSITY · PI WENTE, SUSAN R. · 2010 to 2019
$5.6M
MOLECULAR ANALYSIS OF NUCLEAR PORE COMPLEX FUNCTIONR01GM051219 · NIGMS · WASHINGTON UNIVERSITY · PI WENTE, SUSAN R. · 1994 to 2009
$4.2M
NCI NIH HHS T32CA11925NCI NIH HHS T32 CA119925NIGMS NIH HHS R01 GM051219NIGMS NIH HHS R37 GM051219NIGMS NIH HHS R37GM051219NIGMS NIH HHS U54 GM103511
6 · The paper itself

Abstract

Transcription of mRNA occurs in the nucleus, making the translocation of mRNA across the nuclear envelope (NE) boundary a critical determinant of proper gene expression and cell survival. A major mRNA export route occurs via the NXF1-dependent pathway through the nuclear pore complexes (NPCs) embedded in the NE. However, recent findings have discovered new evidence supporting the existence of multiple mechanisms for crossing the NE, including both NPC-mediated and NE budding-mediated pathways. An analysis of the trans-acting factors and cis components that define these pathways reveals shared elements as well as mechanistic differences. We review here the current understanding of the mechanisms that characterize each pathway and highlight the determinants that influence mRNA transport fate.

Indexed as

RNA TransportActive Transport, Cell NucleusAnimalsCell NucleusDiseaseHumansRNA, MessengerStress, PhysiologicalRNA, MessengerexportinlaminmRNA exportnuclear envelopenuclear pore complextransport

Identifiers

PMID23583578
PMCPMC3729607

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.