ArticleAutonomic neuroscience : basic & clinical2013
Vagal afferent innervation of the lower esophageal sphincter.
Article in Autonomic neuroscience : basic & clinical, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Anatomy and function of efferent and afferent vagal innervation of the stomach.Autonomic neuroscience : basic & clinical · 2026Review
- Article
- Vagal Oxytocin Receptors as Molecular Targets in Gut-Brain Signaling: Implications for Appetite, Satiety, Obesity, and Esophageal Motility-A Narrative Review.International journal of molecular sciences · 2025Review
- Article
- Identification of vagal afferent nerve endings in the mouse colon and their spatial relationship with enterochromaffin cells.Cell and tissue research · 2024Article
- Spinal afferent innervation in flat-mounts of the rat stomach: anterograde tracing.Scientific reports · 2023Article
- Functional anatomy of the vagus system - Emphasis on the somato-visceral interface.Autonomic neuroscience : basic & clinical · 2021Article
- Computational evaluation of laparoscopic sleeve gastrectomy.Updates in surgery · 2021Article
- Murine Esophagus Expresses Glial-Derived Central Nervous System Antigens.International journal of molecular sciences · 2021Article
- Enlightening the frontiers of neurogastroenterology through optogenetics.American journal of physiology. Gastrointestinal and liver physiology · 2020Review
- Acute effects of vagus nerve stimulation parameters on gastric motility assessed with magnetic resonance imaging.Neurogastroenterology and motility · 2020Article
- Vagus Nerves Provide a Robust Afferent Innervation of the Mucosa Throughout the Body of the Esophagus in the Mouse.Dysphagia · 2020Article
- Vagal sensory neurons and gut-brain signaling.Current opinion in neurobiology · 2020Review
- Dissecting the Role of Subtypes of Gastrointestinal Vagal Afferents.Frontiers in physiology · 2020Review
- A novel role for the extracellular matrix glycoprotein-Tenascin-X in gastric function.The Journal of physiology · 2019Article
- Spinal Afferent Innervation of the Colon and Rectum.Frontiers in cellular neuroscience · 2018Article
- Distinct projection targets define subpopulations of mouse brainstem vagal neurons that express the autism-associated MET receptor tyrosine kinase.The Journal of comparative neurology · 2017Article
- Improvement of atropine on esophagogastric junction observation during sedative esophagogastroduodenoscopy.PloS one · 2017Article
- Individual sympathetic postganglionic neurons coinnervate myenteric ganglia and smooth muscle layers in the gastrointestinal tract of the rat.The Journal of comparative neurology · 2016Article
- Vagal Intramuscular Arrays: The Specialized Mechanoreceptor Arbors That Innervate the Smooth Muscle Layers of the Stomach Examined in the Rat.The Journal of comparative neurology · 2016Article
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Authors and funding
8 authors.
Funding
Abstract
To supply a fuller morphological characterization of the vagal afferents innervating the lower esophageal sphincter (LES), specifically to label vagal terminals in the tissues forming the LES in the gastroesophageal junction, the present experiment employed injections of dextran biotin into the nodose ganglia of rats. Four types of vagal afferents innervated the LES. Clasp and sling muscle fibers were directly and prominently innervated by intramuscular arrays (IMAs). Individual IMA terminals subtended about 16° of arc of the esophageal circumference, and, collectively, the terminal fields were distributed within the muscle ring to establish a 360° annulus of mechanoreceptors in the sphincter wall. 3D morphometry of the terminals established that, compared to sling muscle IMAs, clasp muscle IMAs had more extensive arbors and larger receptive fields. In addition, at the cardia, local myenteric ganglia between smooth muscle sheets and striated muscle bundles were innervated by intraganglionic laminar endings (IGLEs), in a pattern similar to the innervation of the myenteric plexus throughout the stomach and esophagus. Finally, as previously described, the principle bundle of sling muscle fibers that links LES sphincter tissue to the antropyloric region of the lesser curvature was innervated by exceptionally long IMAs as well as by unique web ending specializations at the distal attachment of the bundle. Overall, the specialized varieties of densely distributed vagal afferents innervating the LES underscore the conclusion that these sensory projections are critically involved in generating LES reflexes and may be promising targets for managing esophageal dysfunctions.
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