Evidence map›Paper›PMID 23583172›Full record

ArticleThe Journal of thoracic and cardiovascular surgery2014

The effect of preoperative nutritional status on postoperative outcomes in children undergoing surgery for congenital heart defects in San Francisco (UCSF) and Guatemala City (UNICAR).

Monique Radman, Ricardo Mack, Joaquin Barnoya, Aldo Castañeda, Monica Rosales, Anthony Azakie, Nilesh Mehta, Roberta Keller, Sanjeev Datar, Peter Oishi and 1 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of thoracic and cardiovascular surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 4 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 4 syntheses or guidelines pooled it, 149 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. [Clinical effect of feeding with calorie-enriched formula in children with ventricular septal defect and severe pneumonia].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019
    Trial
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  18. Nutrition, dietary recommendations, and supplements for patients with congenital heart disease.International journal of cardiology. Congenital heart disease · 2023
    Review
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  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Monique RadmanPediatrics, University of California, San Francisco, Calif; Cardiovascular Research Institute, University of California, San Francisco, Calif.
Ricardo MackUnidad de Cirugia Cardiovascular de Guatemala, Guatemala City, Guatemala.
Joaquin BarnoyaUnidad de Cirugia Cardiovascular de Guatemala, Guatemala City, Guatemala; Surgery, Washington University, St. Louis, Mo; Division of Public Health Sciences, Washington University, St. Louis, Mo.
Aldo CastañedaUnidad de Cirugia Cardiovascular de Guatemala, Guatemala City, Guatemala.
Monica RosalesUnidad de Cirugia Cardiovascular de Guatemala, Guatemala City, Guatemala.
Anthony AzakieSurgery, University of California, San Francisco, Calif.
Nilesh MehtaPediatrics, Boston Children's Hospital, Boston, Mass.
Roberta KellerPediatrics, University of California, San Francisco, Calif.
Sanjeev DatarPediatrics, University of California, San Francisco, Calif.
Peter OishiPediatrics, University of California, San Francisco, Calif; Cardiovascular Research Institute, University of California, San Francisco, Calif.
Jeffrey FinemanPediatrics, University of California, San Francisco, Calif; Cardiovascular Research Institute, University of California, San Francisco, Calif. Electronic address: jeff.fineman@ucsf.edu.
University of California, San Francisco · USUnidad de Cirugía Cardiovascular de Guatemala · GTBoston Children's Hospital · USWashington University in St. Louis · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Pediatric Critical Care Scientist Development ProgramK12HD047349 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI HEATHER T. KEENAN, Kevin M Watt · 2004 to 2026
$17.0M
PERINATAL PULMONARY HYPERTENSION: DEVELOPMENT MEDIATORSR01HL061284 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FINEMAN, JEFFREY R · 1999 to 2016
$8.3M
Research Training in Pediatric Critical Care MedicineT32HD049303 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JEFFREY R FINEMAN · 2006 to 2026
$3.1M
Chronic Sildenafil for Severe Diaphragmatic HerniaK23HL079922 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KELLER, ROBERTA L · 2005 to 2009
$602k
NCRR NIH HHS UL1 RR024131NCRR NIH HHS UL RR024131NHLBI NIH HHS HL61284NHLBI NIH HHS K23 HL079922NHLBI NIH HHS R01 HL061284NICHD NIH HHS HD049303NICHD NIH HHS T32 HD049303
6 · The paper itself

Abstract

objectiveThe objective of this study was to determine the association between preoperative nutritional status and postoperative outcomes in children undergoing surgery for congenital heart defects (CHD).

methodsSeventy-one patients with CHD were enrolled in a prospective, 2-center cohort study. We adjusted for baseline risk differences using a standardized risk adjustment score for surgery for CHD. We assigned a World Health Organization z score for each subject's preoperative triceps skin-fold measurement, an assessment of total body fat mass. We obtained preoperative plasma concentrations of markers of nutritional status (prealbumin, albumin) and myocardial stress (B-type natriuretic peptide [BNP]). Associations between indices of preoperative nutritional status and clinical outcomes were sought.

resultsSubjects had a median (interquartile range [IQR]) age of 10.2 (33) months. In the University of California at San Francisco (UCSF) cohort, duration of mechanical ventilation (median, 19 hours; IQR, 29 hours), length of intensive care unit stay (median, 5 days; IQR 5 days), duration of any continuous inotropic infusion (median, 66 hours; IQR 72 hours), and preoperative BNP levels (median, 30 pg/mL; IQR, 75 pg/mL) were associated with a lower preoperative triceps skin-fold z score (P < .05). Longer duration of any continuous inotropic infusion and higher preoperative BNP levels were also associated with lower preoperative prealbumin (12.1 ± 0.5 mg/dL) and albumin (3.2 ± 0.1; P < .05) levels.

conclusionsLower total body fat mass and acute and chronic malnourishment are associated with worse clinical outcomes in children undergoing surgery for CHD at UCSF, a resource-abundant institution. There is an inverse correlation between total body fat mass and BNP levels. Duration of inotropic support and BNP increase concomitantly as measures of nutritional status decrease, supporting the hypothesis that malnourishment is associated with decreased myocardial function.

Indexed as

Child Nutritional Physiological PhenomenaNutritional StatusAdiposityBiomarkersCardiac Surgical ProceduresCardiotonic AgentsChild Nutrition DisordersChild, PreschoolFemaleGuatemalaHeart Defects, CongenitalHumansInfantInfant, NewbornInfant Nutrition DisordersLength of StayALB protein, humanBiomarkersCardiotonic AgentsNatriuretic Peptide, BrainPrealbuminSerum AlbuminSerum Albumin, Human182021BMIBNPbody mass indexB-type natriuretic peptidecardiopulmonary bypassCHDCIconfidence intervalcongenital heart diseaseCPBICUintensive care unitLa Unidad de Cirugia Cardiovascular de Guatemalalength of stayLOSPCICUpediatric cardiac intensive care unittriceps skin-fold-for-age z scoreTSFZUCSFUNICARUniversity of California at San FranciscoWHOWorld Health Organization

Identifiers

PMID23583172
PMCPMC3787941
OpenAlexW1965315680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.