ArticleNeuron2013
Closing the gate in the limbic striatum: prefrontal suppression of hippocampal and thalamic inputs.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Heterosynaptic Interactions between the Dorsal and Ventral Hippocampus in Individual Medium Spiny Neurons of the Nucleus Accumbens Ventromedial Shell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Evenamide reverses schizophrenia-related dysfunction in a neurodevelopmental animal model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Heterosynaptic interactions between dorsal and ventral hippocampus in individual medium spiny neurons of the nucleus accumbens ventromedial shell.bioRxiv : the preprint server for biology · 2025Article
- Sex-biased neural encoding of threat discrimination in nucleus accumbens afferents drives suppression of reward behavior.Nature neuroscience · 2024Article
- Updating the striatal-pallidal wiring diagram.Nature neuroscience · 2024Review
- A quadruple dissociation of reward-related behaviour in mice across excitatory inputs to the nucleus accumbens shell.Communications biology · 2023Article
- Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding.Nature communications · 2021Article
- Binge Alcohol Drinking Alters Synaptic Processing of Executive and Emotional Information in Core Nucleus Accumbens Medium Spiny Neurons.Frontiers in cellular neuroscience · 2021Article
- Adolescent anxiety disorders and the developing brain: comparing neuroimaging findings in adolescents and adults.General psychiatry · 2021Review
- Input Convergence, Synaptic Plasticity and Functional Coupling Across Hippocampal-Prefrontal-Thalamic Circuits.Frontiers in neural circuits · 2018Review
- The Role of Kappa Opioid Receptors in Glutamate Input Selection in the Ventral Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Kappa Opioid Receptors Mediate Heterosynaptic Suppression of Hippocampal Inputs in the Rat Ventral Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Seeing through the smoke: Human and animal studies of cannabis use and endocannabinoid signalling in corticolimbic networks.Neuroscience and biobehavioral reviews · 2017Review
- Effort-Based Reinforcement Processing and Functional Connectivity Underlying Amotivation in Medicated Patients with Depression and Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Effect of Treadmill Running on Morphine Dependence Before and After Medial Prefrontal Cortex Lesion in Rats.Asian journal of sports medicine · 2016Article
- Distinct Corticostriatal and Intracortical Pathways Mediate Bilateral Sensory Responses in the Striatum.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Perimovement decrease of alpha/beta oscillations in the human nucleus accumbens.Journal of neurophysiology · 2016Article
- Prelimbic to Accumbens Core Pathway Is Recruited in a Dopamine-Dependent Manner to Drive Cued Reinstatement of Cocaine Seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Olanzapine Treatment of Adolescent Rats Alters Adult D2 Modulation of Cortical Inputs to the Ventral Striatum.The international journal of neuropsychopharmacology · 2016Article
- Resolving the neural circuits of anxiety.Nature neuroscience · 2015Review
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2 authors.
Funding
Abstract
Many brain circuits control behavior by integrating information arising from separate inputs onto a common target neuron. Neurons in the ventral striatum (VS) receive converging excitatory afferents from the prefrontal cortex (PFC), hippocampus (HP), and thalamus, among other structures, and the integration of these inputs is critical for goal-directed behaviors. Although HP inputs have been described as gating PFC throughput in the VS, recent data reveal that the VS desynchronizes from the HP during epochs of burst-like PFC activity related to decision making. It is therefore possible that PFC inputs locally attenuate responses to other glutamatergic inputs to the VS. Here, we found that delivering trains of stimuli to the PFC suppresses HP- and thalamus-evoked synaptic responses in the VS, in part through activation of inhibitory processes. This interaction may enable the PFC to exert influence on basal ganglia loops during decision-making instances with minimal disturbance from ongoing contextual inputs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.