ArticleNeuron2013
Developmental regulation and activity-dependent maintenance of GABAergic presynaptic inhibition onto rod bipolar cell axonal terminals.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Afferent input differentially regulates establishment and maintenance of synapses in the mammalian retina.Scientific reports · 2025Article
- Developmental expression of α- and β- synuclein in the mouse retina.Brain structure & function · 2025Article
- Cellular and Molecular Mechanisms Regulating Retinal Synapse Development.Annual review of vision science · 2024Review
- Sensory deprivation arrests cellular and synaptic development of the night-vision circuitry in the retina.Current biology : CB · 2023Article
- Transient expression of a GABA receptor subunit during early development is critical for inhibitory synapse maturation and function.Current biology : CB · 2021Article
- Establishment and Maintenance of Neural Circuit Architecture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- LRRTM4: A Novel Regulator of Presynaptic Inhibition and Ribbon Synapse Arrangements of Retinal Bipolar Cells.Neuron · 2020Article
- GABA release selectively regulates synapse development at distinct inputs on direction-selective retinal ganglion cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Assembly and maintenance of GABAergic and Glycinergic circuits in the mammalian nervous system.Neural development · 2018Review
- Eliminating Glutamatergic Input onto Horizontal Cells Changes the Dynamic Range and Receptive Field Organization of Mouse Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Establishing Wiring Specificity in Visual System Circuits: From the Retina to the Brain.Annual review of neuroscience · 2017Review
- Muscle afferent excitability testing in spinal root-intact rats: dissociating peripheral afferent and efferent volleys generated by intraspinal microstimulation.Journal of neurophysiology · 2017Article
- Classification of Mouse Retinal Bipolar Cells: Type-Specific Connectivity with Special Reference to Rod-Driven AII Amacrine Pathways.Frontiers in neuroanatomy · 2017Article
- Early Retinal Neuronal Dysfunction in Diabetic Mice: Reduced Light-Evoked Inhibition Increases Rod Pathway Signaling.Investigative ophthalmology & visual science · 2016Article
- RdgB2 is required for dim-light input into intrinsically photosensitive retinal ganglion cells.Molecular biology of the cell · 2015Article
- Neurotransmission plays contrasting roles in the maturation of inhibitory synapses on axons and dendrites of retinal bipolar cells.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Conditional Knock-Out of Vesicular GABA Transporter Gene from Starburst Amacrine Cells Reveals the Contributions of Multiple Synaptic Mechanisms Underlying Direction Selectivity in the Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- GABAergic neurotransmission and retinal ganglion cell function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- Illuminating the multifaceted roles of neurotransmission in shaping neuronal circuitry.Neuron · 2014Review
- Functional architecture of the retina: development and disease.Progress in retinal and eye research · 2014Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Presynaptic inhibition onto axons regulates neuronal output, but how such inhibitory synapses develop and are maintained in vivo remains unclear. Axon terminals of glutamatergic retinal rod bipolar cells (RBCs) receive GABAA and GABAC receptor-mediated synaptic inhibition. We found that perturbing GABAergic or glutamatergic neurotransmission does not prevent GABAergic synaptogenesis onto RBC axons. But, GABA release is necessary for maintaining axonal GABA receptors. This activity-dependent process is receptor subtype specific: GABAC receptors are maintained, whereas GABAA receptors containing α1, but not α3, subunits decrease over time in mice with deficient GABA synthesis. GABAA receptor distribution on RBC axons is unaffected in GABAC receptor knockout mice. Thus, GABAA and GABAC receptor maintenance are regulated separately. Although immature RBCs elevate their glutamate release when GABA synthesis is impaired, homeostatic mechanisms ensure that the RBC output operates within its normal range after eye opening, perhaps to regain proper visual processing within the scotopic pathway.
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Registered trials
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