Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2013
The bi-directional relationship between parent-child conflict and treatment outcome in treatment-resistant adolescent depression.
Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00018902 (Treatment of SSRI-Resistant Depression in Adolescents), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of SSRI-Resistant Depression in Adolescents (TORDIA)
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- A systematic review of interventions for treatment resistant major depressive disorder in adolescents.European child & adolescent psychiatry · 2020Pooled it
- Children's Maternal Representations Moderate the Efficacy of Parent-Child Interaction Therapy-Emotion Development (PCIT-ED) Treatment For Preschool Depression.Research on child and adolescent psychopathology · 2022Trial
- Parent-teen communication predicts treatment benefit for depressed and suicidal adolescents.Journal of consulting and clinical psychology · 2019Trial
- Impact of treatments for depression on comorbid anxiety, attentional, and behavioral symptoms in adolescents with selective serotonin reuptake inhibitor-resistant depression.Journal of the American Academy of Child and Adolescent Psychiatry · 2013Trial
- Relationships Between Adolescent Perception of Family Functioning and Affective Symptomatology.JAACAP open · 2025Article
- Major challenges in youth psychopathology: treatment-resistant depression. A narrative review.Frontiers in psychiatry · 2024Review
- Development, reach, acceptability and associated clinical changes of a group intervention to improve caregiver-adolescent relationships in the context of adolescent depression.JCPP advances · 2023Article
- Article
- Social Support and Parental Conflict as Predictors of Outcomes of Group Cognitive Behavioral Therapy for Adolescent Depression.International journal of cognitive therapy · 2023Article
- Measurement-based care for suicidal youth: Outcomes and recommendations from the Services for Teens At Risk (STAR) Center.PloS one · 2023Article
- Predictors, Moderators, and Mediators Associated With Treatment Outcome in Randomized Clinical Trials Among Adolescents With Depression: A Scoping Review.JAMA network open · 2022Article
- Positive Relationships with Adults and Resilience to Suicide Attempt among New Mexico Hispanic Adolescents.International journal of environmental research and public health · 2021Article
- Parent-youth conflict as a predictor of depression in adulthood: a 15-year follow-up of a community-based cohort.European child & adolescent psychiatry · 2020Article
- Annual Research Review: Defining and treating pediatric treatment-resistant depression.Journal of child psychology and psychiatry, and allied disciplines · 2020Review
- Marital and Parent-Child Relationships during Treatment for Adolescent Depression: Child-Driven and Bidirectional Effects.Journal of abnormal child psychology · 2019Article
- Antidepressant Prescribing by Pediatricians: A Mixed-Methods Analysis.Current problems in pediatric and adolescent health care · 2017Article
- Neural Plasticity in Obesity and Psychiatric Disorders.Neural plasticity · 2016Article
- Extending parent-child interaction therapy for early childhood internalizing problems: new advances for an overlooked population.Clinical child and family psychology review · 2014Review
- Family support programs and adolescent mental health: review of evidence.Adolescent health, medicine and therapeutics · 2014Review
- Depression in Childhood and Early Adolescence: Parental Expressed Emotion and Family Functioning.Annals of depression and anxietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 11 institutions in 3 countries.
Funding
Abstract
objectiveTo examine the bidirectional relationship between parent-child discord and treatment outcome for adolescent treatment-resistant depression.
methodDepressed youth who had not responded to an adequate course of a selective serotonin reuptake inhibitor (SSRI) were randomized to either a switch to another SSRI or venlafaxine, with or without the addition of cognitive behavior therapy (CBT) in the Treatment of SSRI-Resistant Depression in Adolescents (TORDIA) study. The Conflict Behavior Questionnaire was used to assess adolescent (CBQ-A) and parent-reported (CBQ-P) parent-child discord. The impact of remission on parent-child conflict, and the differential impact of medication and CBT on the CBQ-A and CBQ-P, were assessed using generalized linear models.
resultsAlthough there were no differential treatment effects on parent or adolescent-report of conflict, remission was associated with improvement in the CBQ-P. In general, intake family conflict did not predict remission, except in the sub-group of participants whose parents reported clinically significant parent-child conflict at intake, for whom high levels of parent-reported conflict predicted a lower likelihood of remission. Conflict also did not moderate treatment response.
conclusionsRemission of depression may be sufficient to reduce parent-reported parent-child conflict. However, higher parent-reported conflict, in the clinically significant range, predicts a lower likelihood of remission from depression. Clinical trial registration information-Treatment of SSRI-Resistant Depression in Adolescents (TORDIA); http://clinicaltrials.gov/; NCT00018902.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.