ArticleBiological psychiatry2014
Impulsivity is associated with uric acid: evidence from humans and mice.
Article in Biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Purinergic system dysfunction in mood disorders: a key target for developing improved therapeutics.Progress in neuro-psychopharmacology & biological psychiatry · 2015Pooled it
- Article
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- Aggression and Justice Involvement: Does Uric Acid Play a Role?Brain sciences · 2025Article
- Uric Acid: A Biomarker and Pathogenic Factor of Affective Disorders and Neurodegenerative Diseases.Current pharmaceutical design · 2025Review
- The Prevalence of Hyperuricemia and the Association Between Hyperuricemia and Age in Patients with Psychiatric Disorders to a General Hospital: A Cross-Section Study.International journal of general medicine · 2024Article
- Associations between dietary habits and bipolar disorder: a diet-wide mendelian randomization study.Frontiers in psychiatry · 2024Article
- Multiomic approach and Mendelian randomization analysis identify causal associations between blood biomarkers and subcortical brain structure volumes.NeuroImage · 2023Article
- Dysuricemia-A New Concept Encompassing Hyperuricemia and Hypouricemia.Biomedicines · 2023Review
- Multiomic approach and Mendelian randomization analysis identify causal associations between blood biomarkers and subcortical brain structure volumes.medRxiv : the preprint server for health sciences · 2023Article
- Do thrifty genes exist? Revisiting uricase.Obesity (Silver Spring, Md.) · 2022Review
- The Purinergic System as a Target for the Development of Treatments for Bipolar Disorder.CNS drugs · 2022Review
- Oxidative Stress and Psychiatric Disorders: Evidence from the Bidirectional Mendelian Randomization Study.Antioxidants (Basel, Switzerland) · 2022Article
- Does fructose have a protective role on migraine?-experimental evidence in a rat model of metabolic syndrome under omega-3 supplementation.Annals of translational medicine · 2022Article
- The prevalence and associated clinical correlates of hyperuricemia in patients with bipolar disorder.Frontiers in neuroscience · 2022Article
- Peripheral non-enzymatic antioxidants as biomarkers for mood disorders: Evidence from a machine learning prediction model.Frontiers in psychiatry · 2022Article
- Genetic Correlation Analysis and Transcriptome-wide Association Study Suggest the Overlapped Genetic Mechanism between Gout and Attention-deficit Hyperactivity Disorder.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2021Article
- Association between serum uric acid and depressive symptoms stratified by low-grade inflammation status.Scientific reports · 2021Article
- Individuals with bipolar disorder have a higher level of uric acid than major depressive disorder: a case-control study.Scientific reports · 2021Article
- Inflammatory signaling mechanisms in bipolar disorder.Journal of biomedical science · 2021Review
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe ability to control impulses varies greatly, and difficulty with impulse control can have severe consequences; in the extreme, it is the defining feature of many psychiatric disorders. Evidence from disparate lines of research suggests that uric acid is elevated in psychiatric disorders characterized by high impulsivity, such as attention-deficit/hyperactivity disorder and bipolar disorder. The present research tests the hypothesis that impulsivity is associated with higher uric acid in humans and mice.
methodsUsing two longitudinal, nonclinical community samples (total n = 6883), we tested whether there is an association between uric acid and normal variation in trait impulsivity measured with the Revised NEO Personality Inventory. We also examined the effect of uric acid on behavior by comparing wild-type mice, which naturally have low levels of uric acid, with mice genetically modified to accumulate high levels of uric acid.
resultsIn both human samples, the emotional aspects of trait impulsivity, specifically impulsiveness and excitement seeking, were associated with higher levels of uric acid concurrently and when uric acid was measured 3 to 5 years later. Consistent with the human data, the genetically modified mice displayed significantly more exploratory and novelty-seeking behavior than the wild-type mice.
conclusionsHigher uric acid was associated with impulsivity in both humans and mice. The identification of biological markers of impulsivity may lead to a better understanding of the physiological mechanisms involved in impulsivity and may suggest potential targets for therapeutic intervention.
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