ReviewJournal of long-term effects of medical implants2012
Factors influencing the long-term behavior of extracellular matrix-derived scaffolds for musculoskeletal soft tissue repair.
Review in Journal of long-term effects of medical implants, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Multilayered electrospun scaffolds for tendon tissue engineering.Tissue engineering. Part A · 2013Trial
- Tendon healing in the era of regenerative medicine: literature review.Annals of translational medicine · 2026Review
- Tendon-derived matrix crosslinking techniques for electrospun multi-layered scaffolds.Journal of biomedical materials research. Part A · 2023Article
- Engineered Tissue Graft for Repair of Injured Infraspinatus Rotator Cuff Tendon.Tissue engineering. Part A · 2023Article
- Tuning the Degradation Rate of Alginate-Based Bioinks for Bioprinting Functional Cartilage Tissue.Biomedicines · 2022Article
- The Role of Scaffolds in Tendon Tissue Engineering.Journal of functional biomaterials · 2020Review
- Human Adipose-Derived Mesenchymal Stem Cells-Incorporated Silk Fibroin as a Potential Bio-Scaffold in Guiding Bone Regeneration.Polymers · 2020Article
- Current Status of Tissue-Engineered Scaffolds for Rotator Cuff Repair.Techniques in orthopaedics (Rockville, Md.) · 2016Article
- Extracellular matrix-based biomaterial scaffolds and the host response.Biomaterials · 2016Review
- The current state of scaffolds for musculoskeletal regenerative applications.Nature reviews. Rheumatology · 2015Review
- Fatigue damage of collagenous tissues: experiment, modeling and simulation studies.Journal of long-term effects of medical implants · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Musculoskeletal connective tissues such as tendon, ligament, and cartilage possess a limited ability for self-repair. Tissue engineering seeks to use combinations of cells, bioactive molecules, and biomaterials to develop new treatment options for the repair or replacement of damaged tissues. The use of native extracellular matrix as scaffold material for tissue engineering has become increasingly attractive because such tissues can not only provide structural support, but also regulate cell behavior. Although demineralized bone matrix has long been recognized for its osteoinductive abilities, recent studies have identified the ability of cartilage and tendon extracellular matrices to stimulate the differentiation of mesenchymal or adipose-derived adult stem cells toward chondrogenic or tenogenic lineages, respectively. This review discusses the motivation for fabricating scaffolds from musculoskeletal tissues, the in vitro and in vivo efficacy of these tissue-derived scaffolds, and various processing techniques such as decellularization or cross-linking that can mitigate immunogenic responses, moderate the degradation profile, and enhance the mechanical properties of these constructs following long-term implantation in vivo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.