ReviewClinical transplantation
Vascularized composite tissue allotransplantation--state of the art.
Review in Clinical transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Malignancies after vascularized composite allotransplantation.Frontiers in immunology · 2026Pooled it
- Immunological considerations and outcomes in cross-sex vascularized composite allotransplantation.Clinical transplantation and research · 2026Review
- Review
- Clustering and predicting VCA patient populations - a machine learning approach into vascularized composite allotransplantation.Frontiers in immunology · 2026Article
- Molecular Signature Associated With Acute Rejection in Vascularized Composite Allotransplantation.Transplantation direct · 2024Article
- Exploring Costimulatory Blockade-Based Immunologic Strategies in Transplantation: Are They a Promising Immunomodulatory Approach for Organ and Vascularized Composite Allotransplantation?Journal of personalized medicine · 2024Review
- Reconstructive Paradigms: A Problem-Solving Approach in Complex Tissue Defects.Journal of clinical medicine · 2024Review
- Exceeding the Limits of Static Cold Storage in Limb Transplantation Using Subnormothermic Machine Perfusion.Journal of reconstructive microsurgery · 2023Article
- Facial Transplantation: Complications, Outcomes, and Long-Term Management Strategies.Seminars in plastic surgery · 2020Review
- Multiphase Assembly of Small Molecule Microcrystalline Peptide Hydrogel Allows Immunomodulatory Combination Therapy for Long-Term Heart Transplant Survival.Small (Weinheim an der Bergstrasse, Germany) · 2020Article
- Cellular Mechanisms of Rejection of Optic and Sciatic Nerve Transplants: An Observational Study.Transplantation direct · 2020Article
- Costimulation Blockade in Vascularized Composite Allotransplantation.Frontiers in immunology · 2020Review
- The landscape of vascularized composite allograft donation in the United States.Current opinion in organ transplantation · 2019Review
- Applied Bioengineering in Tissue Reconstruction, Replacement, and Regeneration.Tissue engineering. Part B, Reviews · 2019Review
- Absence of Rejection in a Facial Allograft Recipient with a Positive Flow Crossmatch 24 Months after Induction with Rabbit Anti-Thymocyte Globulin and Anti-CD20 Monoclonal Antibody.Case reports in transplantation · 2018Article
- Therapeutic application of T regulatory cells in composite tissue allotransplantation.Journal of translational medicine · 2017Review
- Role of "reduced-size" liver/bowel grafts in the "abdominal wall transplantation" era.World journal of gastrointestinal surgery · 2017Review
- Outcomes after hand and upper extremity transplantation.Journal of materials science. Materials in medicine · 2017Review
- Vascularized composite allotransplantation: current standards and novel approaches to prevent acute rejection and chronic allograft deterioration.Transplant international : official journal of the European Society for Organ Transplantation · 2016Review
- Extracellular Matrix Revisited: Roles in Tissue Engineering.International neurourology journal · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Vascularized composite tissue allotransplantation is a viable treatment option for injuries and defects that involve multiple layers of functional tissue. In the past 15 yr, more than 150 vascularized composite allotransplantation (VCA) surgeries have been reported for various anatomic locations including - but not limited to - trachea, larynx, abdominal wall, face, and upper and lower extremities. VCA can achieve a level of esthetic and functional restoration that is currently unattainable using conventional reconstructive techniques. Although the risks of lifelong immunosuppression continue to be an important factor when evaluating the benefits of VCA, reported short- and long-term outcomes have been excellent, thus far. Acute rejections are common in the early post-operative period, and immunosuppression-related side effects have been manageable. A multidisciplinary approach to the management of VCA has proven successful. Reports of long-term graft losses have been rare, while several factors may play a role in the pathophysiology of chronic graft deterioration in VCA. Alternative approaches to immunosuppression such as cellular therapies and immunomodulation hold promise, although their role is so far not defined. Experimental protocols for VCA are currently being explored. Moving forward, it will be exciting to see whether VCA-specific aspects of allorecognition and immune responses will be able to help facilitate tolerance induction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.