ReviewAntioxidants & redox signaling2013
Proline mechanisms of stress survival.
Review in Antioxidants & redox signaling, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 390 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
390 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,154 citations in OpenAlex.
- Multi-omics of oxidative stress and particulate matter exposure: a systematic review.Respiratory research · 2026Pooled it
- Proline concentrations in seedlings of woody plants change with drought stress duration and are mediated by seed characteristics: a meta-analysis.Scientific reports · 2023Pooled it
- Metabolomic Profiles Associated With Blood Pressure Reduction in Response to the DASH and DASH-Sodium Dietary Interventions.Hypertension (Dallas, Tex. : 1979) · 2023Trial
- The circular RNA circP5CS1 coordinates plant immunity by sequestering miR167 to modulate ARF6/8 signaling and repressing P5CS1-mediated proline biosynthesis in Arabidopsis.Plant communications · 2026Article
- Nematicidal and plant growth-promoting potential of the cell-free culture supernatant of Bacillus megaterium in tomato under Meloidogyne incognita infection: an in vitro and in vivo study.Archives of microbiology · 2026Article
- Crosstalk in the cold: host-microbe interactions in insect diapause.Annals of the Entomological Society of America · 2026Review
- Proline Dehydrogenase GeneJournal of fungi (Basel, Switzerland) · 2026Article
- Antioxidant Compounds in Microalgae and Cyanobacteria: A Sustainable Source of Bioactive Molecules.Marine drugs · 2026Review
- Proline: A Reliable Biochemical Marker of Plant Abiotic Stress Tolerance?Plants (Basel, Switzerland) · 2026Review
- Physiological and molecular investigation of nanosilica mediated drought tolerance in cumin (Cuminum cyminum L.).Scientific reports · 2026Article
- Metabolic Plasticity Versus Conservative Strategies: How Nitrogen Form and Foliar Proline Modulate Genotypic Heat Stress Responses in Tomato.Plants (Basel, Switzerland) · 2026Article
- PYCR1 modulates ferroptosis and malignant phenotypes of clear cell renal cell carcinoma through proline biosynthesis.Molecular biology reports · 2026Article
- Trait Plasticity, Resource Redirection and Strong Recovery Capacity EnhancePlants (Basel, Switzerland) · 2026Article
- Compatible Solute Variation and Stress Adaptation in Native Qatari Plants: Focus on Proline.Life (Basel, Switzerland) · 2026Review
- Fungal endophytes of cactus (mSphere · 2026Article
- Alkamines reveal a hidden layer of steroid and drug metabolism.bioRxiv : the preprint server for biology · 2026Article
- Evaluating the phytoremediation capacity of Verbesina encelioides through lead-induced morphological and biochemical shifts.Biodegradation · 2026Article
- Integrated morpho-physiological and biochemical responses of wheat genotypes to terminal heat stress and their role in determining grain yield.Scientific reports · 2026Article
- Integrated Biochemical and Ultrastructural Responses ofPlants (Basel, Switzerland) · 2026Article
- Influence of drought stress on the metabolite and ion composition in nectar and nectaries of different day- and night-flowering Nicotiana species.Plant biology (Stuttgart, Germany) · 2026Article
330 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
significanceThe imino acid proline is utilized by different organisms to offset cellular imbalances caused by environmental stress. The wide use in nature of proline as a stress adaptor molecule indicates that proline has a fundamental biological role in stress response. Understanding the mechanisms by which proline enhances abiotic/biotic stress response will facilitate agricultural crop research and improve human health. RECENT ADVANCES: It is now recognized that proline metabolism propels cellular signaling processes that promote cellular apoptosis or survival. Studies have shown that proline metabolism influences signaling pathways by increasing reactive oxygen species (ROS) formation in the mitochondria via the electron transport chain. Enhanced ROS production due to proline metabolism has been implicated in the hypersensitive response in plants, lifespan extension in worms, and apoptosis, tumor suppression, and cell survival in animals. CRITICAL ISSUES: The ability of proline to influence disparate cellular outcomes may be governed by ROS levels generated in the mitochondria. Defining the threshold at which proline metabolic enzyme expression switches from inducing survival pathways to cellular apoptosis would provide molecular insights into cellular redox regulation by proline. Are ROS the only mediators of proline metabolic signaling or are other factors involved? FUTURE DIRECTIONS: New evidence suggests that proline biosynthesis enzymes interact with redox proteins such as thioredoxin. An important future pursuit will be to identify other interacting partners of proline metabolic enzymes to uncover novel regulatory and signaling networks of cellular stress response.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.