ArticleRevista brasileira de hematologia e hemoterapia2013
Hyperglycemia increases the complicated infection and mortality rates during induction therapy in adult acute leukemia patients.
Article in Revista brasileira de hematologia e hemoterapia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Development and Validation of a Prognostic Risk Score for Patients With Cancer and Neutropenic Fever Presenting to the Emergency Department.Journal of the American College of Emergency Physicians open · 2026Article
- An Interpretable Machine Learning Framework for Rare Disease: A Case Study to Stratify Infection Risk in Pediatric Leukemia.Journal of clinical medicine · 2024Article
- Stress hyperglycemia is associated with poor prognosis in critically ill patients with cardiogenic shock.Frontiers in endocrinology · 2024Article
- Current cancer therapies and their influence on glucose control.World journal of diabetes · 2021Review
- Azacitidine-induced hyperglycaemia.BMJ case reports · 2019Article
- Association between glycemic control, age, and outcomes among intensively treated patients with acute myeloid leukemia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- Comorbidity, Physical Function, and Quality of Life in Older Adults with Acute Myeloid Leukemia.Current geriatrics reports · 2017Article
- Measurement of Hyperglycemia and Impact on Health Outcomes in People With Cancer: Challenges and Opportunities.Oncology nursing forum · 2017Review
- Safe and effective dosing of basal-bolus insulin in patients receiving high-dose steroids for hyper-cyclophosphamide, doxorubicin, vincristine, and dexamethasone chemotherapy.Diabetes technology & therapeutics · 2014Article
- Stress-induced hyperglycemia is a valuable biomarker in febrile neutropenia.Revista brasileira de hematologia e hemoterapia · 2013Article
- The association of hyperglycemia with the development of infectious complications in adult Filipino patients with acute lymphoblastic leukemia.Hematology, transfusion and cell therapyArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the prevalence of hyperglycemia during induction therapy in adult patients with acute leukemia and its effect on complicated infections and mortality during the first 30 days of treatment.
methodsAn analysis was performed in a retrospective cohort of 280 adult patients aged 18 to 60 years with previously untreated acute leukemia who received induction chemotherapy from January 2000 to December 2009 at the Hemocentro de Pernambuco (HEMOPE), Brazil. Hyperglycemia was defined as the finding of at least one fasting glucose measurement > 100 mg/dL observed one week prior to induction therapy until 30 days after. The association between hyperglycemia and complicated infections, mortality and complete remission was evaluated using the Chi-square or Fisher's exact tests by the Statistical Package for Social Sciences (SPSS) in the R software package version 2.9.0.
resultsOne hundred and eighty-eight patients (67.1%) presented hyperglycemia at some moment during induction therapy. Eighty-two patients (29.3%) developed complicated infections. Infection-related mortality during the neutropenia period was 20.7% (58 patients). Mortality from other causes during the first 30 days after induction was 2.8%. Hyperglycemia increased the risk of complicated infections (OR 3.97; 95% confidence interval: 2.08 - 7.57; p-value < 0.001) and death (OR 3.55; 95% confidence interval: 1.77-7.12; p-value < 0.001) but did not increase the risk of fungal infections or decrease the probability of achieving complete remission.
conclusionThis study demonstrates an association between the presence of hyperglycemia and the development of complicated infections and death in adult patients during induction therapy for acute leukemia.
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