ReviewCold Spring Harbor perspectives in medicine2013
Systems level neuroplasticity in drug addiction.
Review in Cold Spring Harbor perspectives in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Voluntary wheel running during adolescence prevents the increase in ethanol intake induced by social defeat in male mice.Psychopharmacology · 2025Article
- A Comprehensive Overview of Stress, Resilience, and Neuroplasticity Mechanisms.International journal of molecular sciences · 2025Review
- Frontal white and gray matter abnormality in gambling disorder: A multimodal MRI study.Journal of behavioral addictions · 2024Article
- Analysis of theInternational journal of molecular sciences · 2024Article
- Ethanol-Induced Suppression of G Protein-Gated Inwardly Rectifying KBiological psychiatry · 2023Article
- Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression.Pharmacology, biochemistry, and behavior · 2023Article
- Dopamine dysfunction in stimulant use disorders: mechanistic comparisons and implications for treatment.Molecular psychiatry · 2022Review
- Growth Factors and Alcohol Use Disorder.Cold Spring Harbor perspectives in medicine · 2020Review
- Chasing the addicted engram: identifying functional alterations in Fos-expressing neuronal ensembles that mediate drug-related learned behavior.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- Dose response of acute cocaine on sleep/waking behavior in mice.Neurobiology of sleep and circadian rhythms · 2018Article
- Rat animal models for screening medications to treat alcohol use disorders.Neuropharmacology · 2017Review
- Nucleus Accumbens AMPA Receptor Trafficking Upregulated by Food Restriction: An Unintended Target for Drugs of Abuse and Forbidden Foods.Current opinion in behavioral sciences · 2016Article
- Synaptic mechanisms underlying persistent cocaine craving.Nature reviews. Neuroscience · 2016Review
- Brain white matter integrity in heroin addicts during methadone maintenance treatment is related to relapse propensity.Brain and behavior · 2016Article
- Sex differences in drug addiction and response to exercise intervention: From human to animal studies.Frontiers in neuroendocrinology · 2016Review
- Corticostriatal BDNF and alcohol addiction.Brain research · 2015Review
- Emotional graphic cigarette warning labels reduce the electrophysiological brain response to smoking cues.Addiction biology · 2015Article
- Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models.British journal of pharmacology · 2014Review
- Assessment of a proposed "three-criteria" cocaine addiction model for use in reinstatement studies with rats.Psychopharmacology · 2014Article
- Risky decision making, prefrontal cortex, and mesocorticolimbic functional connectivity in methamphetamine dependence.JAMA psychiatry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Drug addiction is a chronic relapsing disorder for which research has been dedicated to understand the various factors that contribute to development, loss of control, and persistence of compulsive addictive behaviors. In this review, we provide a broad overview of various theories of addiction, drugs of abuse, and the neurobiology involved across the addiction cycle. Specific focus is devoted to the role of the mesolimbic pathway in acute drug reinforcement and occasional drug use, the mesocortical pathway and associated areas (e.g., the dorsal striatum) in escalation/dependence, and the involvement of these pathways and associated circuits in mediating conditioned responses, drug craving, and loss of behavioral control thought to underlie withdrawal and relapse. With a better understanding of the neurobiological factors that underlie drug addiction, continued preclinical and clinical research will aid in the development of novel therapeutic interventions that can serve as effective long-term treatment strategies for drug-dependent individuals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.