ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2013
Peeling back the evolutionary layers of molecular mechanisms responsive to exercise-stress in the skeletal muscle of the racing horse.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- Genetic characterisation of the Connemara pony and the Warmblood horse using a within-breed clustering approach.Genetics, selection, evolution : GSE · 2023Article
- Genomic characterization of the world's longest selection experiment in mouse reveals the complexity of polygenic traits.BMC biology · 2022Article
- Regulation of toll-like receptors expression in muscle cells by exercise-induced stress.Animal bioscience · 2021Article
- Validation of exercise-response genes in skeletal muscle cells of Thoroughbred racing horses.Animal bioscience · 2021Article
- Joint Estimates of Heterozygosity and Runs of Homozygosity for Modern and Ancient Samples.Genetics · 2019Article
- Effects of exercise on myokine gene expression in horse skeletal muscles.Asian-Australasian journal of animal sciences · 2019Article
- Characterization of gene expression and genetic variation of horse ERBB receptor feedback inhibitor 1 in Thoroughbreds.Asian-Australasian journal of animal sciences · 2018Article
- Large Deletions at the SHOX Locus in the Pseudoautosomal Region Are Associated with Skeletal Atavism in Shetland Ponies.G3 (Bethesda, Md.) · 2016Article
- Whole mitochondrial genomes unveil the impact of domestication on goat matrilineal variability.BMC genomics · 2015Article
- Genome-wide analysis of DNA methylation before-and after exercise in the thoroughbred horse with MeDIP-Seq.Molecules and cells · 2015Article
- Copy number deletion has little impact on gene expression levels in racehorses.Asian-Australasian journal of animal sciences · 2014Article
- Thoroughbred Horse Single Nucleotide Polymorphism and Expression Database: HSDB.Asian-Australasian journal of animal sciences · 2014Article
- Article
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Authors and funding
24 authors.
Funding
Abstract
The modern horse (Equus caballus) is the product of over 50 million yrs of evolution. The athletic abilities of the horse have been enhanced during the past 6000 yrs under domestication. Therefore, the horse serves as a valuable model to understand the physiology and molecular mechanisms of adaptive responses to exercise. The structure and function of skeletal muscle show remarkable plasticity to the physical and metabolic challenges following exercise. Here, we reveal an evolutionary layer of responsiveness to exercise-stress in the skeletal muscle of the racing horse. We analysed differentially expressed genes and their co-expression networks in a large-scale RNA-sequence dataset comparing expression before and after exercise. By estimating genome-wide dN/dS ratios using six mammalian genomes, and FST and iHS using re-sequencing data derived from 20 horses, we were able to peel back the evolutionary layers of adaptations to exercise-stress in the horse. We found that the oldest and thickest layer (dN/dS) consists of system-wide tissue and organ adaptations. We further find that, during the period of horse domestication, the older layer (FST) is mainly responsible for adaptations to inflammation and energy metabolism, and the most recent layer (iHS) for neurological system process, cell adhesion, and proteolysis.
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Registered trials
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