ArticleJournal of magnetic resonance imaging : JMRI2013
Measurement of interscapular brown adipose tissue of mice in differentially housed temperatures by chemical-shift-encoded water-fat MRI.
Article in Journal of magnetic resonance imaging : JMRI, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Randomization, design and analysis for interdependency in aging research: no person or mouse is an island.Nature aging · 2022Article
- Subcutaneous fat necrosis in newborns: a systematic literature review of case reports and model of pathophysiology.Molecular and cellular pediatrics · 2022Review
- University of Alabama at Birmingham Nathan Shock Center: comparative energetics of aging.GeroScience · 2021Review
- Human Brown Adipose Tissue Estimated With Magnetic Resonance Imaging Undergoes Changes in Composition After Cold Exposure: AnFrontiers in endocrinology · 2019Article
- Non-invasive methods for the assessment of brown adipose tissue in humans.The Journal of physiology · 2018Review
- The Impact of Housing Temperature-Induced Chronic Stress on Preclinical Mouse Tumor Models and Therapeutic Responses: An Important Role for the Nervous System.Advances in experimental medicine and biology · 2017Article
- Contributors to Metabolic Disease Risk Following Spinal Cord Injury.Current physical medicine and rehabilitation reports · 2016Article
- Thermogenic profiling using magnetic resonance imaging of dermal and other adipose tissues.JCI insight · 2016Article
- PreclinicalFrontiers in pharmacology · 2016Review
- Dielectric properties measurements of brown and white adipose tissue in rats from 0.5 to 10 GHz.Biomedical physics & engineering express · 2016Article
- Brown adipose tissue dynamics in wild-type and UCP1-knockout mice: in vivo insights with magnetic resonance.Journal of lipid research · 2014Article
- MRI detection of brown adipose tissue with low fat content in newborns with hypothermia.Magnetic resonance imaging · 2014Observational
- Quantitative proton MR techniques for measuring fat.NMR in biomedicine · 2013Review
- In vivo noninvasive detection of Brown Adipose Tissue through intermolecular zero-quantum MRI.PloS one · 2013Article
- Chemical-shift water-fat MRI of white adipose depots: inability to resolve cell size differences.International journal of body composition research · 2013Article
- Article
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Authors and funding
5 authors.
Funding
Abstract
purposeTo determine differences in fat-signal fraction (FF) from chemical-shift-encoded water-fat MRI of interscapular BAT in mice housed at different ambient temperatures (Ta ). MATERIALS AND
methodsC57BL/6J male mice (8 weeks old) were singly housed at 16°C, 23°C, or 30°C (n = 16/group) for 4 weeks. Measures included food intake, body weight (both measured weekly) and body composition (at baseline, 2, and 4 weeks post-thermal exposure); chemical-shift-encoded water-fat MRI was performed on a 9.4 Tesla Bruker magnet with respiratory gating and anesthesia at 4 weeks post-thermal exposure.
resultsA significant inverse relationship between food intake and Ta was evidenced (P < 0.0001). Lean mass was similar among groups, while total fat mass was significantly different among groups ([mean ± SE]: 30°C = 5.10 ± 0.19 g; 23°C = 4.18 ± 0.16 g; 16°C = 3.48 ± 0.54 g; P < 0.0001). Mean BAT-FF was positively related to Ta (means: 30°C = 79.4%; 23°C = 61.8%; 16°C = 50.9%; P < 0.0001).
conclusionThese cross-sectional results demonstrate that MRI measurement of FF within the interscapular BAT in mice reflects recent functional status of the tissue, with a lower Ta leading to a significantly reduced BAT-FF, indicative of the tissue's involvement in thermogenesis.
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