Evidence map›Paper›PMID 23580378›Full record

Trial reportThe British journal of psychiatry : the journal of mental science2013

Age differences in treatment response to a collaborative care intervention for anxiety disorders.

Julie Loebach Wetherell, Andrew J Petkus, Steven R Thorp, Murray B Stein, Denise A Chavira, Laura Campbell-Sills, Michelle G Craske, Cathy Sherbourne, Alexander Bystritsky, Greer Sullivan and 1 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The British journal of psychiatry : the journal of mental science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00347269 (Coordinated Anxiety Learning and Management), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00347269 phase4completednot on this map

Coordinated Anxiety Learning and Management (CALM): Improving Primary Care Anxiety Outcomes

TypeinterventionalSponsorUniversity of WashingtonRan2006 to 2009Enrolled1,004ConditionsPost-traumatic Stress Disorder, Generalized Anxiety Disorder, Panic Disorder, Social Anxiety DisorderArmsCognitive-behavioral therapy, Psychotropic medication optimization, Treatment as Usual
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.

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  7. Insights Following Implementation of an Exercise Intervention in Older Veterans with PTSD.International journal of environmental research and public health · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Julie Loebach WetherellDepartment of Psychiatry, 9500 Gilman Drive, Dept. 9111N-1, La Jolla, CA 92093-9111, USA. jwetherell@ucsd.edu
Andrew J Petkus
Steven R Thorp
Murray B Stein
Denise A Chavira
Laura Campbell-Sills
Michelle G Craske
Cathy Sherbourne
Alexander Bystritsky
Greer Sullivan
Peter Roy-Byrne
University of California, San Diego · USUniversity of California, Los Angeles · USRAND Corporation · USSan Diego State University · USUniversity of Arkansas at Little Rock · USUniversity of Washington · USVA San Diego Healthcare System · US

Funding

CALM: Improving Primary Care Anxiety OutcomesU01MH057835 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STEIN, MURRAY B. · 2005 to 2009
$3.3M
CALM: IMPROVING PRIMARY CARE ANXIETY OUTCOMESU01MH070018 · NIMH · RAND CORPORATION · PI SHERBOURNE, CATHY D · 2005 to 2009
$3.1M
CALM: Improving Primary Care Anxiety OutcomesU01MH058915 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CRASKE, MICHELLE G · 2005 to 2009
$3.0M
CALM: Improving Primary Care OutcomesU01MH057858 · NIMH · UNIVERSITY OF WASHINGTON · PI ROY-BYRNE, PETER PAUL · 2005 to 2009
$2.4M
CALM: Improving Primary Care Anxiety OutcomesU01MH070022 · NIMH · UNIV OF ARKANSAS FOR MED SCIS · PI SULLIVAN, JAN GREER · 2005 to 2009
$2.3M
Improving Patient Outcomes in Anxiety DisordersK24MH064122 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STEIN, MURRAY B. · 2001 to 2011
$1.3M
Treating Anxiety in Public Sector Medical SettingsK24MH065324 · NIMH · UNIVERSITY OF WASHINGTON · PI ROY-BYRNE, PETER PAUL · 2003 to 2007
$661k
NIMH NIH HHS K24 MH064122NIMH NIH HHS K24 MH065324NIMH NIH HHS K24 MH64122NIMH NIH HHS U01 MH057835NIMH NIH HHS U01MH057835NIMH NIH HHS U01 MH057858NIMH NIH HHS U01 MH058915NIMH NIH HHS U01MH058915NIMH NIH HHS U01 MH070018NIMH NIH HHS U01 MH070022
6 · The paper itself

Abstract

backgroundSome data suggest that older adults with anxiety disorders do not respond as well to treatment as do younger adults.

aimsWe examined age differences in outcomes from the Coordinated Anxiety Learning and Management (CALM) study, an effectiveness trial comparing usual care to a computer-assisted collaborative care intervention for primary care patients with panic disorder, generalised anxiety disorder, post-traumatic stress disorder (PTSD), and/or social anxiety disorder. This is the first study to examine the efficacy of a collaborative care intervention in a sample that included both younger and older adults with anxiety disorders. We hypothesised that older adults would show a poorer response to the intervention than younger adults.

methodWe examined findings for the overall sample, as well as within each diagnostic category (clinicaltrials.gov identifier: NCT00347269).

resultsThe CALM intervention was more effective than usual care among younger adults overall and for those with generalised anxiety disorder, panic disorder and social anxiety disorder. Among older adults, the intervention was effective overall and for those with social anxiety disorder and PTSD but not for those with panic disorder or generalised anxiety disorder. The effects of the intervention also appeared to erode by the 18-month follow-up, and there were no significant effects on remission among the older adults.

conclusionsThese results are consistent with the findings of other investigators suggesting that medications and psychotherapy for anxiety disorders may not be as effective for older individuals as they are for younger people.

Indexed as

AdolescentAdultAgedAge FactorsAnti-Anxiety AgentsAnxiety DisordersCognitive Behavioral TherapyCombined Modality TherapyFemaleHumansMaleMiddle AgedTherapy, Computer-AssistedTreatment OutcomeAnti-Anxiety Agents

Identifiers

PMID23580378
PMCPMC3696879
OpenAlexW2155162860

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.