ArticleJournal of neurovirology2013
Autonomic dysfunction is common in HIV and associated with distal symmetric polyneuropathy.
Article in Journal of neurovirology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02850276 (Autonomic Neuropathy, Gastrointestinal Motility, and Inflammation in HIV), which is not on this map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Autonomic Neuropathy, Gastrointestinal Motility, and Inflammation in HIV
Who cites it
37 citing papers in PubMed, 67 citations in OpenAlex.
- The effect of pyridostigmine on small intestinal bacterial overgrowth (SIBO) and plasma inflammatory biomarkers in HIV-associated autonomic neuropathies.Journal of neurovirology · 2019Trial
- A Mixed-Methods Pilot Study of Mindfulness-Based Stress Reduction for HIV-Associated Chronic Pain.Behavioral medicine (Washington, D.C.)Trial
- Characterizing multimorbidity and the risk for hospitalization among people living with HIV from the African Cohort Study.BMC global and public health · 2026Article
- Parkinsonism in people with virally suppressed HIV.The lancet. HIV · 2026Review
- Gastrointestinal Dysmotility, Autonomic Function, and Small Intestinal Bacterial Overgrowth Among People With Well-Controlled HIV.The Journal of infectious diseases · 2025Article
- Autonomic neuropathy is associated with an increase in type-1 cytokines in people living with HIV.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Autonomic Neuropathy Is Associated with An Increase in Type-1 Cytokines in People Living With HIV.bioRxiv : the preprint server for biology · 2025Article
- Peripheral neuropathy and associated factors among children living with HIV on antiretroviral therapy in Gamo zone, Southern Ethiopia: an institution-based cross-sectional study.BMC infectious diseases · 2024Article
- The severity of distal sensory polyneuropathy increasing with HIV/AIDS stage.The Pan African medical journal · 2024Article
- Autonomic Neuropathy is Associated with More Densely Interconnected Cytokine Networks in People with HIV.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023Article
- Autonomic Neuropathy as a Predictor of Morbidity and Mortality in People Living With HIV: A Retrospective, Longitudinal Cohort Study.Neurology. Clinical practice · 2023Article
- Phenotyping autonomic neuropathy using principal component analysis.Autonomic neuroscience : basic & clinical · 2023Article
- Direct and indirect cardiovascular and cardiometabolic sequelae of the combined anti-retroviral therapy on people living with HIV.Frontiers in physiology · 2023Review
- Neuropathogenesis of HIV and emerging therapeutic targets.Expert opinion on therapeutic targets · 2022Review
- HIV-associated painful neuropathy: where are we?Arquivos de neuro-psiquiatria · 2022Article
- Interpreting resting heart rate variability in complex populations: the role of autonomic reflexes and comorbidities.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Assessment of Autonomic Nervous System Dysfunction in the Early Phase of Infection With SARS-CoV-2 Virus.Frontiers in neuroscience · 2021Article
- Blockade of beta adrenergic receptors protects the blood brain barrier and reduces systemic pathology caused by HIV-1 Nef protein.PloS one · 2021Article
- Sympathetic function and markers of inflammation in well-controlled HIV.Brain, behavior, & immunity - health · 2020Article
- Refined Quantitation of Sweat Gland Innervation.Journal of neuropathology and experimental neurology · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Neurologic complications of HIV are well characterized in the central and peripheral nervous systems but not in the autonomic nervous system, perhaps due to the complexities of measuring autonomic function in medically ill populations. We hypothesized that autonomic dysfunction is common in HIV, can be meaningfully measured with an autonomic reflex screen, and is associated with distal symmetric polyneuropathy (DSP) but not with signs of CNS disease. We also sought to characterize immunovirologic and medical factors associated with autonomic dysfunction. We assessed 102 HIV-infected adults for autonomic dysfunction with a laboratory-based autonomic reflex screen summarized as the composite autonomic severity score (CASS). The total neuropathy score (TNS) was used to quantify DSP based on neurologic interview/examination, quantitative sensory testing, and nerve conduction studies. Autonomic dysfunction was common, with a CASS ≥ 3 in 61 % of participants, of whom 86 % were symptomatic. Greater CASS abnormalities demonstrated univariate association with increasing TNS, age, viral load, hypertension, and use of medications (particularly anticholinergics), but not with antiretrovirals, current/nadir CD(4+) count, HIV duration, metabolic factors, or signs of CNS disease. The TNS was the only significant predictor of the CASS in multivariate analysis; anticholinergic medications were marginally significant. This study demonstrates that autonomic dysfunction is common and frequently symptomatic in HIV and that an autonomic reflex screen, adjusted for anticholinergic medication, is useful in its assessment. Association of autonomic dysfunction with DSP suggests common factors in their pathogenesis, and autonomic neuropathy may be part of the spectrum of HIV-associated peripheral nerve pathologies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.