ArticleEuropean archives of psychiatry and clinical neuroscience2013
Lifetime cannabis use and cognition in patients with schizophrenia spectrum disorders and their unaffected siblings.
Article in European archives of psychiatry and clinical neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Iowa Gambling Task: Men and Women Perform Differently. A Meta-analysis.Neuropsychology review · 2025Pooled it
- Long-term cognitive trajectories and heterogeneity in patients with schizophrenia and their unaffected siblings.Acta psychiatrica Scandinavica · 2018Article
- Therapeutic potential of medicinal marijuana: an educational primer for health care professionals.Drug, healthcare and patient safety · 2018Review
- Gone to Pot - A Review of the Association between Cannabis and Psychosis.Frontiers in psychiatry · 2014Review
- Therapeutic targets in major psychiatric disorders revisited.European archives of psychiatry and clinical neuroscience · 2013Article
- Effects of cannabis and familial loading on subcortical brain volumes in first-episode schizophrenia.European archives of psychiatry and clinical neuroscience · 2013Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between cannabis and cognitive performance is controversial. While both acute administration and long-term cannabis use impair cognitive performance in healthy subjects, several studies have shown improved cognitive outcomes in patients with schizophrenia spectrum disorders who use cannabis. The aim of this study was to determine the relationship between lifetime cannabis use, as assessed longitudinally over 10 years of follow-up in a sample of 42 patients and 35 of their unaffected siblings, and current cognitive performance. Forty-two healthy control subjects were assessed at follow-up with the same instruments. Stepwise linear regression revealed a negative effect of longitudinal cannabis use on performance in a social cognition task in the patient group. In the sibling group, lifetime cannabis use had a negative effect on processing speed and declarative memory performance. In the control group, cannabis use per se did not predict cognitive performance; however, when adding lifetime tobacco use to the model, we found a negative association between lifetime cannabis and tobacco use and processing speed and social cognition performance. Moreover, a lower IQ associated with current cannabis use predicted worse attentional performance in the control group. The differential pattern of associations between cannabis use and cognitive performance in patients compared with siblings and controls can be explained by the negative impact of illness on cognition.
Indexed as
Identifiers
23580110What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.