ReviewInternational journal of molecular sciences2013
Influence of melatonin on the immune system of fish: a review.
Review in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 66 citations in OpenAlex.
- Impacts of Long-Term High-Temperature and Low-Salinity Stress on the Circadian Rhythms of Antioxidant, Immune, and Endocrine Systems in Turbot (Antioxidants (Basel, Switzerland) · 2026Article
- Induced swimming reduced stress and modulated immune response and antioxidant status in juvenile rainbow trout (Oncorhynchus mykiss).Fish physiology and biochemistry · 2025Article
- Dietary Melatonin Supplementation Improved Intestinal Health and Immune Function of Pacific White Shrimp (Life (Basel, Switzerland) · 2025Article
- Dietary Melatonin Boosts Reproduction and Growth Performance of Ornamental Fish Giant Danio (Aquaculture nutrition · 2025Article
- Cardiac function in Vimba vimba embryos under electromagnetic exposure at hatchery-relevant intensities.PloS one · 2025Article
- Melatonin Alleviates Copper Toxicity via Improving ROS Metabolism and Antioxidant Defense Response in Tomato Seedlings.Antioxidants (Basel, Switzerland) · 2022Article
- Zebrafish as a Tool in the Study of Sleep and Memory-related Disorders.Current neuropharmacology · 2022Review
- Melatonin integrates multidimensional regulation of NaFrontiers in physiology · 2022Article
- Evolutionary Genomics Reveals Multiple Functions of ArylalkylamineFrontiers in genetics · 2022Review
- Melatonin as a Potential Adjuvant Treatment for COVID-19 beyond Sleep Disorders.International journal of molecular sciences · 2021Review
- Effects of melatonin on protecting against lung injury (Review).Experimental and therapeutic medicine · 2021Review
- Seasonal simulated photoperiods influence melatonin release and immune markers of pike perch Sander lucioperca.Scientific reports · 2020Article
- Effects of Sex Steroids on Fish Leukocytes.Biology · 2018Review
- Rhythms in the endocrine system of fish: a review.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endocrine-immune system interactions have been widely demonstrated in mammals, whereas in fish, these relationships remain unclear. Of the organs that constitute the endocrine system, the pineal gland and its secretory product melatonin act in the synchronization of daily and seasonal rhythms in most vertebrates, including fish. Seasonal differences in immunocompetence and disease prevalence have been well documented in humans. Seasonality also strongly influences the life history of fish by controlling the timing of physiological events, such as reproduction, food intake, locomotor activity, and growth performance. Apart from its synchronizing capabilities, the role of melatonin in physiological processes in fish is not thoroughly understood. The purpose of this review is to summarize current studies on the effects of melatonin on the fish immune system. These studies suggest that melatonin represents an important component of fish endocrine-immune system interactions. The elucidation of the defense mechanisms of fish will facilitate the development of health management tools to support the growing finfish aquaculture industry as well as address questions concerning the origins and evolution of the immune system in vertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.