ArticleInternational journal of molecular sciences2013
Connexin 26 is down-regulated by KDM5B in the progression of bladder cancer.
Article in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer.Communications biology · 2023Article
- Pan-cancer analysis of the prognostic and immunological role of GJB2: a potential target for survival and immunotherapy.Frontiers in oncology · 2023Review
- KDM5B expression in cisplatin resistant neuroblastoma cell lines.Oncology letters · 2022Article
- Article
- Review
- Jumonji AT-rich interactive domain 1B promotes the growth of pancreatic tumors via the phosphatase and tensin homolog/protein kinase B signaling pathway.Oncology letters · 2018Article
- KDM5B overexpression predicts a poor prognosis in patients with squamous cell carcinoma of the head and neck.Journal of Cancer · 2018Article
- Histone demethylase lysine demethylase 5B in development and cancer.Oncotarget · 2017Review
- Overexpression of JARID1B promotes differentiation via SHIP1/AKT signaling in human hypopharyngeal squamous cell carcinoma.Cell death & disease · 2016Article
- Regulation of connexin signaling by the epigenetic machinery.Biochimica et biophysica acta · 2016Review
- KDM5B is overexpressed in gastric cancer and is required for gastric cancer cell proliferation and metastasis.American journal of cancer research · 2015Article
- Possible role of hemichannels in cancer.Frontiers in physiology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Connexin 26 (Cx26) expression is down-regulated and KDM5B (H3K4 demethylase) is up-regulated in the progression of bladder cancer, suggesting that Cx26 expression may be down-regulated by KDM5B in bladder cancer. To test the hypothesis, the HT1376 and T24 human bladder carcinoma cells were transfected with the plasmids pcDNA3.1-KDM5B, and caused the down-regulation of Cx26 expression. In contrast, the HT1376 and T24 cells transfected with the plasmids pTZU6+1-shRNA-KDM5B1 and pTZU6+1-shRNA-KDM5B2 caused the up-regulation of Cx26 expression. Immunohistochemistry and Spearman's rank correlation analysis showed that the immunohistochemical expression of KDM5B and Cx26 was inversely related in bladder carcinoma tissues but no relationship in benign tissues. Taken together, these results indicate that KDM5B represses Cx26 expression in the bladder cancer development. Thus, a negative value to Cx26 immunohistochemical expression and a positive value to KDM5B immunohistochemical expression could be an ancillary diagnosis of primary bladder malignancy.
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