Evidence map›Paper›PMID 23579939›Full record

ReviewAlcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism2010

Focus on: Alcohol and the liver.

Gyongyi Szabo, Pranoti Mandrekar

Abstract readReview
In one paragraph

Review in Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gyongyi SzaboDivision of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.
Pranoti Mandrekar
University of Massachusetts Chan Medical School · US

Funding

Role of heat shock protein 90 in alcoholic liver diseaseR01AA017986 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Pranoti Mandrekar · 2009 to 2026
$6.7M
Regulation of MCP-1 and chemokine receptor 2 (CCR2) in alcoholic liver diseaseR21AA017545 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MANDREKAR, PRANOTI · 2010 to 2010
$247k
NIAAA NIH HHS R01 AA017986NIAAA NIH HHS R21 AA017545
6 · The paper itself

Abstract

Thirty-five years ago Charles Lieber and colleagues (1975) published a seminal article in liver research, showing that alcohol itself is the primary cause for the higher prevalence of liver disease seen in alcoholic patients and not dietary deficiencies and malnutrition that often accompany alcoholism. Their groundbreaking research dispelled previously held theories that alcohol was not a major cause of liver damage and led to several decades of study of the deleterious effects of alcohol and its metabolism on the liver. Since that early study, clinical and experimental studies have continued to show a firm connection between high amounts of alcohol consumption and liver disease. This article tracks advances in alcohol-related liver disease research over the past 40 years and describes how these discoveries are helping scientists to gain insight into therapeutic targets that may help to combat this life-threatening disease.

Indexed as

Alcohol DrinkingAlcoholismAnimalsHumansLiverLiver Diseases, Alcoholic

Identifiers

PMID23579939
PMCPMC3860520
OpenAlexW2107005309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.