ArticleAlcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism2010
Genetic research: who is at risk for alcoholism.
Article in Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Recent advances in alcohol metabolism: from the gut to the brain.Physiological reviews · 2025Review
- Recent Efforts to Dissect the Genetic Basis of Alcohol Use and Abuse.Biological psychiatry · 2020Review
- Enhanced alcohol degradation and hepatic protective effects of anLaboratory animal research · 2020Article
- Peripheral Acid Sphingomyelinase Activity Is Associated with Biomarkers and Phenotypes of Alcohol Use and Dependence in Patients and Healthy Controls.International journal of molecular sciences · 2018Article
- AUDIT-C and ICD codes as phenotypes for harmful alcohol use: association with ADH1B polymorphisms in two US populations.Addiction (Abingdon, England) · 2018Article
- Parental Problem Drinking and Emerging Adult Problem Behavior: The Moderating Role of Parental Support.Journal of child and family studies · 2018Article
- Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B.Alcoholism, clinical and experimental research · 2017Observational
- The interactive effect of paternal problem drinking and maternal problem drinking on adolescent internalizing problems.Addictive behaviors · 2015Article
- Frequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathways.Translational psychiatry · 2015Article
- Differential expression and functional role of cannabinoid genes in alcohol users.Drug and alcohol dependence · 2013Article
- A multistep general theory of transition to addiction.Psychopharmacology · 2013Article
- Genetics and alcoholism.Nature reviews. Gastroenterology & hepatology · 2013Review
- Translational behaviour-genetic studies of alcohol: are we there yet?Genes, brain, and behavior · 2012Review
- Bridging Animal and Human Models: Translating From (and to) Animal Genetics.Alcohol research : current reviews · 2012Article
- Pharmacotherapy for alcohol use disorder: current and emerging therapies.Harvard review of psychiatryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) was founded 40 years ago to help elucidate the biological underpinnings of alcohol dependence, including the potential contribution of genetic factors. Twin, adoption, and family studies conclusively demonstrated that genetic factors account for 50 to 60 percent of the variance in risk for developing alcoholism. Case-control studies and linkage analyses have helped identify DNA variants that contribute to increased risk, and the NIAAA-sponsored Collaborative Studies on Genetics of Alcoholism (COGA) has the expressed goal of identifying contributing genes using state-of-the-art genetic technologies. These efforts have ascertained several genes that may contribute to an increased risk of alcoholism, including certain variants encoding alcohol-metabolizing enzymes and neurotransmitter receptors. Genome-wide association studies allowing the analysis of millions of genetic markers located throughout the genome will enable discovery of further candidate genes. In addition to these human studies, genetic animal models of alcohol's effects and alcohol use have greatly advanced our understanding of the genetic basis of alcoholism, resulting in the identification of quantitative trait loci and allowing for targeted manipulation of candidate genes. Novel research approaches-for example, into epigenetic mechanisms of gene regulation-also are under way and undoubtedly will further clarify the genetic basis of alcoholism.
Indexed as
Identifiers
23579937PMC3887503W1527276324What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.