ArticleEcoHealth2013
Natural stressors and ranavirus susceptibility in larval wood frogs (Rana sylvatica).
Article in EcoHealth, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 87 citations in OpenAlex.
- Testing the Population-Level Effects of Stress-Induced Susceptibility in the Ranavirus-Wood Frog System.Ecology and evolution · 2025Article
- Age- and dose-dependent susceptibility of axolotls (Ambystoma mexicanum) by bath exposure to Ambystoma tigrinum virus (ATV).Virology · 2023Article
- Diet- and salinity-induced modifications of the gut microbiota are associated with differential physiological responses to ranavirus infection inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Differentiating metabolomic responses of amphibians to multiple stressors.The Science of the total environment · 2022Article
- Endogenous Retroviruses Augment Amphibian (Xenopus laevis) Tadpole Antiviral Protection.Journal of virology · 2022Article
- Article
- Ranavirus Amplification in Low-Diversity Amphibian Communities.Frontiers in veterinary science · 2022Article
- The Roles of Amphibian (Viruses · 2021Article
- Amphibian (Frontiers in immunology · 2021Article
- Article
- Amphibian (Viruses · 2018Article
- The influence of landscape and environmental factors on ranavirus epidemiology in a California amphibian assemblage.Freshwater biology · 2018Article
- Differentiation-dependent antiviral capacities of amphibian (The Journal of biological chemistry · 2018Article
- Amphibian (Frontiers in immunology · 2018Article
- Review of the Amphibian Immune Response to Chytridiomycosis, and Future Directions.Frontiers in immunology · 2018Review
- Ranaviruses and reptiles.PeerJ · 2018Article
- Xenopus-FV3 host-pathogen interactions and immune evasion.Virology · 2017Article
- Host food resource supplementation increases echinostome infection in larval anurans.Parasitology research · 2016Article
- Water Temperature Affects Susceptibility to Ranavirus.EcoHealth · 2016Article
- Prominent amphibian (Xenopus laevis) tadpole type III interferon response to the frog virus 3 ranavirus.Journal of virology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic exposure to stressors has been shown to suppress immune function in vertebrates, making them more susceptible to pathogens. It is less clear, however, whether many natural stressors are immunosuppressive. Moreover, whether stressors make disease more likely or more severe in populations is unclear because animals respond to stressors both behaviorally and physiologically. We tested whether chronic exposure to three natural stressors of wood frog tadpoles-high-densities, predator-cues, and low-food conditions-influence their susceptibility to a lethal ranavirus both individually in laboratory experiments, and collectively in outdoor mesocosms. Prior to virus exposure, we observed elevated corticosterone only in low-food treatments, although other treatments altered rates of growth and development as well as tadpole behavior. None of the treatments, however, increased susceptibility to ranavirus as measured by the proportion of tadpoles that became infected or died, or the time to death compared to controls. In fact, mortality in the mesocosms was actually lower in the high-density treatment even though most individuals became infected, largely because of increased rates of metamorphosis. Overall we find no support for the hypothesis that chronic exposure to common, ecologically relevant challenges necessarily elevates corticosterone levels in a population or leads to more severe ranaviral disease or epidemics. Conditions may, however, conspire to make ranavirus infection more common in metamorphosing amphibians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.