ArticleThe EMBO journal1990
Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 138 citations in OpenAlex.
- Circulating DNA as prognostic biomarker in patients with advanced hepatocellular carcinoma: a translational exploratory study from the SORAMIC trial.Journal of translational medicine · 2019Trial
- Hepatocellular adenoma: Where are we now?World journal of gastroenterology · 2022Article
- Novel Genetic Rearrangements in Hepatitis B Virus: Complex Structural Variations and Structural Variation Polymorphisms.Viruses · 2021Review
- Circulating Cell-Free DNA Combined to Magnetic Resonance Imaging for Early Detection of HCC in Patients with Liver Cirrhosis.Cancers · 2021Article
- The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences.Stem cell research & therapy · 2019Review
- Chimeric RNA in Cancer and Stem Cell Differentiation.Stem cells international · 2018Review
- Decellularization and Solubilization of Porcine Liver for Use as a Substrate for Porcine Hepatocyte Culture: Method Optimization and Comparison.Cell transplantation · 2017Article
- New Tools for Molecular Therapy of Hepatocellular Carcinoma.Diseases (Basel, Switzerland) · 2015Review
- Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.American journal of human genetics · 2008Article
- Genetics of hepatocellular tumors.Oncogene · 2006Review
- Article
- Alteration of C-MYB DNA binding to cognate responsive elements in HL-60 variant cells.Molecular pathology : MP · 2002Article
- Liver enriched transcription factors and differentiation of hepatocellular carcinoma.Molecular pathology : MP · 1999Review
- Regulation of hepatitis B virus expression in progenitor and differentiated cell types: evidence for negative transcriptional control in nonpermissive cells.Gene expression · 1999Article
- Hepatocyte nuclear factor 4 provokes expression of epithelial marker genes, acting as a morphogen in dedifferentiated hepatoma cells.The Journal of cell biology · 1998Article
- An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types.Nucleic acids research · 1998Article
- Liver-enriched transcription factors uncoupled from expression of hepatic functions in hepatoma cell lines.Molecular and cellular biology · 1997Article
- Hepatocyte nuclear factor-4 prevents silencing of hepatocyte nuclear factor-1 expression in hepatoma x fibroblast cell hybrids.Nucleic acids research · 1997Article
- Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells.Molecular and cellular biology · 1997Article
- The activity of the highly inducible mouse phenylalanine hydroxylase gene promoter is dependent upon a tissue-specific, hormone-inducible enhancer.Molecular and cellular biology · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The promoter proximal sequences of a group of liver-specific genes including that of albumin interact with the same hepato-specific factor named HNF1, LFB1, APF or HP1, a distant member of the homeoprotein family. A distinct protein, termed variant HNF1 (vHNF1), of lower mol. wt but displaying identical sequence specificity is found both in dedifferentiated variants and in an extinguished somatic hybrid that fail to express most or all of the tissue-specific traits, including albumin. We show here that HNF1 transcripts are present only in differentiated hepatoma cells. No transcripts are detected in dedifferentiated variants or in the extinguished cell hybrid, strongly suggesting that the vHNF1 protein is encoded by a distinct gene. Finally, HNF1 transcripts reappear in revertants to the hepatic phenotype. Run-on transcription analysis in isolated nuclei demonstrates that the expression of HNF1 in these cell lines is regulated primarily at the transcriptional level. Contrary to HNF1, the mRNAs coding for two other nuclear factors involved in albumin transcription, C/EBP and NF1, do not follow the distribution of albumin transcripts in these cell lines. These results indicate that extinction in somatic hybrids or loss of expression upon dedifferentiation of liver-specific genes possessing an HNF1 recognition site is caused, at least in part, by a block in HNF1 gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.