ReviewWorld journal of urology2013
Etiology of chronic prostatitis/chronic pelvic pain syndrome: psychoimmunoneurendocrine dysfunction (PINE syndrome) or just a really bad infection?
Review in World journal of urology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Immunostimulation in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS): a one-year prospective, double-blind, placebo-controlled study.World journal of urology · 2014Trial
- Effect and Mechanism of Aloin in Ameliorating Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Network Pharmacology and Experimental Verification.Drug design, development and therapy · 2025Article
- Efficacy and brain modulation mechanisms of acupuncture for chronic prostatitis/chronic pelvic pain syndrome revealed by structural MRI changes.Frontiers in neurology · 2025Article
- Causal effect of gut microbiota on the risk of prostatitis: a two-sample Mendelian randomization study.International urology and nephrology · 2024Article
- Low intensity extracorporeal shockwave therapy for chronic pelvic pain syndrome: Long-term follow-up.Open medicine (Warsaw, Poland) · 2023Article
- Functional mixed effects clustering with application to longitudinal urologic chronic pelvic pain syndrome symptom data.Journal of the American Statistical Association · 2022Article
- Network Pharmacology and Molecular Docking Verify the Mechanism of Qinshi Simiao San in Treating Chronic Prostatitis in the Rat Model.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- The functional connectivity of the basal ganglia subregions changed in mid-aged and young males with chronic prostatitis/chronic pelvic pain syndrome.Frontiers in human neuroscience · 2022Article
- Neuroinflammatory gene expression in chronic prostatitis/chronic pelvic pain syndrome patients: insights into etiology and phenotype biology.Translational andrology and urology · 2021Article
- Beneficial Effects of Inflammatory Cytokine-Targeting Aptamers in an Animal Model of Chronic Prostatitis.International journal of molecular sciences · 2020Article
- Article
- Differential expression of immune factor between patients with chronic prostatitis/chronic pelvic pain syndrome and the healthy volunteers.International urology and nephrology · 2018Article
- Chronic prostatitis/chronic pelvic pain syndrome is associated with previous colonoscopy.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2017Article
- Immunological Mechanisms Underlying Chronic Pelvic Pain and Prostate Inflammation in Chronic Pelvic Pain Syndrome.Frontiers in immunology · 2017Review
- Histopathological classification criteria of rat model of chronic prostatitis/chronic pelvic pain syndrome.International urology and nephrology · 2015Article
- Impact of prostate inflammation on lesion development in the POET3(+)Pten(+/-) mouse model of prostate carcinogenesis.The American journal of pathology · 2014Article
- Strange Vibes - Novel Presentation of Prostatitis.Urology case reports · 2014Article
- Understanding chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).World journal of urology · 2013Article
- Outcomes of holmium laser enucleation of the prostate in men with a history of prostatitis: a retrospective study.Therapeutic advances in urologyArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo review the etiology and pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).
methodsA literature review for the years 1985-2012 was performed using the MEDLINE database of the United States National Library of Medicine.
resultsThe evidence for ongoing infection in men with CP/CPPS is lacking. However, men with CP/CPPS are twice as likely to have had a sexually transmitted disease (STD), and bacteria from men with CP/CPPS may be phenotypically different from those that cause cystitis or acute prostatitis. Evidence continues to support an alteration in both the afferent and efferent autonomic nervous systems. Functional brain imaging suggests changes in the gray matter as well as the importance of the anterior insula and anterior cingulated gyrus in pain processing. Neural function can be modulated by immune and endocrine factors. Alterations in cytokine function and autoimmunity appear to play a role in the immune dysfunction. Alterations in the hypothalamic-pituitary-adrenal axis can mediate the endocrine effects, similar to many other chronic pain conditions. Genetics may play a role in who may develop chronic pain after an initial insult. Finally, any biological changes must then be processed through the psychosocial environment, including the tendency to catastrophize, and degree of spousal support, to produce a given individual patient's pain experience.
conclusionsInfection with atypical bacteria or sequelae of an STD may lead to CP/CPPS in some men. Such a biological insult in the context of alterations in psychoimmunoneurendocrine factors produces the chronic pain experience.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.