Trial reportEuropean journal of applied physiology2013
Cerebral oxygenation during hyperoxia-induced increase in exercise tolerance for untrained men.
Trial report in European journal of applied physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Effects of exercise and vasodilators on cerebral tissue oxygenation in pulmonary hypertension.Lung · 2015Trial
- Endurance training induces asymmetric brain oxygenation adaptations in the left and right prefrontal cortex during submaximal exercise.European journal of applied physiology · 2026Article
- Muscle and cerebral oxygenation during exercise in fibromyalgia: a near-infrared spectroscopy study.European journal of applied physiology · 2026Article
- Hyperoxia improves exercise capacity in cardiopulmonary disease: a series of randomised controlled trials.ERJ open research · 2023Article
- Oxygen-enriched air reduces breathing gas consumption over air.Current research in physiology · 2022Article
- The Effect of Hyperoxia on Central and Peripheral Factors of Arm Flexor Muscles Fatigue Following Maximal Ergometer Rowing in Men.Frontiers in physiology · 2022Article
- Affective and Enjoyment Responses to Sprint Interval Exercise at Different Hypoxia Levels.International journal of environmental research and public health · 2021Article
- Effect of Breathing Oxygen-Enriched Air on Exercise Performance in Patients With Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction: A Randomized, Placebo-Controlled, Crossover Trial.Frontiers in medicine · 2021Article
- Is Structured Exercise Performed with Supplemental Oxygen a Promising Method of Personalized Medicine in the Therapy of Chronic Diseases?Journal of personalized medicine · 2020Article
- Hypoxia equally reduces the respiratory compensation point and the NIRS-derived [HHb] breakpoint during a ramp-incremental test in young active males.Physiological reports · 2020Article
- Autonomic and Cognitive Function Response to Normobaric Hyperoxia Exposure in Healthy Subjects. Preliminary Study.Medicina (Kaunas, Lithuania) · 2020Article
- Acute Low-Dose Hyperoxia during a Single Bout of High-Intensity Interval Exercise Does Not Affect Red Blood Cell Deformability and Muscle Oxygenation in Trained Men-A Randomized Crossover Study.Sports (Basel, Switzerland) · 2020Article
- A Comparison of V̇OInternational journal of exercise science · 2020Article
- Aerobic Interval Training Impacts Muscle and Brain Oxygenation Responses to Incremental Exercise.Frontiers in physiology · 2019Article
- Article
- The Effects of Hyperoxia on Sea-Level Exercise Performance, Training, and Recovery: A Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2018Review
- The Impact of Hyperoxia on Human Performance and Recovery.Sports medicine (Auckland, N.Z.) · 2017Review
- Cerebral and Muscle Tissue Oxygenation During Incremental Cycling in Male Adolescents Measured by Time-Resolved Near-Infrared Spectroscopy.Pediatric exercise science · 2016Article
- Article
- The impact of pedal rate on muscle oxygenation, muscle activation and whole-body VO₂ during ramp exercise in healthy subjects.European journal of applied physiology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to investigate the involvement of cerebral oxygenation in limitation of maximal exercise. We hypothesized that O2 supplementation improves physical performance in relation to its effect on cerebral oxygenation during exercise. Eight untrained men (age 27 ± 6 years; VO2 max 45 ± 8 ml min(-1) kg(-1)) performed two randomized exhaustive ramp exercises on a cycle ergometer (1 W/3 s) under normoxia and hyperoxia (FIO2 = 0.3). Cerebral (ΔCOx) and muscular (ΔMOx) oxygenation responses to exercise were monitored using near-infrared spectroscopy. Power outputs corresponding to maximal exercise intensity, to threshold of ΔCOx decline (ThCOx) and to the respiratory compensation point (RCP) were determined. Power output (W max = 302 ± 20 vs. 319 ± 28 W) and arterial O2 saturation estimated by pulse oximetry (SpO2 = 95.7 ± 0.9 vs. 97.0 ± 0.5 %) at maximal exercise were increased by hyperoxia (P < 0.05). However, the ΔMOx response during exercise was not significantly modified with hyperoxia. RCP (259 ± 17 vs. 281 ± 25 W) and ThCOx (259 ± 23 vs. 288 ± 30 W) were, however, improved (P < 0.05) with hyperoxia and the ThCOx shift was related to the W max improvement with hyperoxia (r = 0.71, P < 0.05). The relationship between the change in cerebral oxygenation response to exercise and the performance improvement with hyperoxia supports that cerebral oxygenation is limiting the exercise performance in healthy young subjects.
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Registered trials
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