ArticleJournal of neuro-oncology2013
Tumor origin and growth pattern at diagnosis and surgical hypothalamic damage predict obesity in pediatric craniopharyngioma.
Article in Journal of neuro-oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review: Sleep Disorders Based on Objective Data in Children and Adolescents Treated for a Brain Tumor.Frontiers in neuroscience · 2022Pooled it
- Cardiac autonomic dysfunction is associated with hypothalamic damage in patients with childhood-onset craniopharyngioma.PloS one · 2021Trial
- Hypothalamic obesity in pediatric vs. adult craniopharyngioma: mechanisms, management, and cardiometabolic outcomes.Pituitary · 2026Review
- Hypothalamic syndrome and acquired hypothalamic obesity: from fragmented care to integrated multidisciplinary management.Pituitary · 2026Review
- Postoperative weight gain following endoscopic endonasal surgery for craniopharyngiomas in children and adults: A retrospective cohort study.Pituitary · 2025Article
- Virtual Reality and Three-Dimensional Printing of Craniopharyngioma: A Case Report Proposing an Innovative Model of Pediatric Endocrine Care to Enhance Patient Engagement.Clinical case reports · 2025Article
- A case-based review of adult-onset craniopharyngioma.Frontiers in endocrinology · 2025Review
- The clinical significance of inflammatory mediators in predicting obesity and progression-free survival in patients with adult-onset Craniopharyngioma.BMC cancer · 2024Article
- The effect of hypothalamic involvement and growth hormone treatment on cardiovascular risk factors during the transition period in patients with childhood-onset craniopharyngioma.Annals of pediatric endocrinology & metabolism · 2023Article
- Effects of Craniotomy and Endoscopic Endonasal Transsphenoidal Surgery on Bodyweight in Adult-Onset Craniopharyngioma: A Single-Center Retrospective Study.Journal of clinical medicine · 2023Article
- Secondary Narcolepsy as Worsening Sign in a Pediatric Case of Optic Pathway Glioma.Children (Basel, Switzerland) · 2022Article
- Preoperative BMI Predicts Postoperative Weight Gain in Adult-onset Craniopharyngioma.The Journal of clinical endocrinology and metabolism · 2021Article
- Craniopharyngioma adherence: a reappraisal of the evidence.Neurosurgical review · 2020Review
- Chemical meningitis in children as a risk factor following craniopharyngioma resection - a case report.BMC neurology · 2020Article
- Craniopharyngioma.Nature reviews. Disease primers · 2019Review
- Successful surgery of the hypothalamic region: Yes, we can!Endocrine · 2018Article
- Long-term endocrine effects and trends in body mass index changes in patients with childhood-onset brain tumors.Journal of neuro-oncology · 2018Article
- Nonalcoholic fatty liver disease in long-term survivors of childhood-onset craniopharyngioma.Annals of pediatric endocrinology & metabolism · 2017Article
- Craniopharyngioma and hypothalamic injury: latest insights into consequent eating disorders and obesity.Current opinion in endocrinology, diabetes, and obesity · 2016Review
- A Case of Slipped Capital Femoral Epiphysis in Association With Craniopharyngioma.Trauma monthly · 2015Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe obesity is a major problem in pediatric craniopharyngioma. We investigated whether tumor origin, growth pattern, and surgical damage predict obesity in pediatric craniopharyngioma. Subjects were 58 patients (30 males) with no tumor recurrence during the first postoperative 18 months. Preoperative hypothalamic involvement was classified into no (pre_G0, n = 19), little (pre_G1, n = 21), and severe (pre_G2, n = 18) involvement groups based on sub- or supradiaphragmatic tumor origin and growth patterns. Postoperative hypothalamic involvement was classified into no (post_G0, n = 4), minimal (post_G1, n = 19), and significant (post_G2, n = 35) involvement groups according to follow-up imaging. The prevalence of obesity increased from 13.2 % at diagnosis (mean age = 8.1 years) to 37.9 % at last follow-up (mean duration = 9.1 years). Only the body mass index (BMI) Z-score increment of the first postoperative year (first-year ΔBMI_Z) was significant (P = 0.007). Both the preoperative BMI_Z (P = 0.001) and the first-year ΔBMI_Z (P = 0.017) showed an increasing trend from the pre_G0 to pre_G1 to pre_G2 group. For the 40 patients with pre_G0 or pre_G1, the first-year ΔBMI_Z was higher in the post_G2 group than the post_G1 group (0.02 ± 0.91 vs. 0.89 ± 0.72, P = 0.003). Tumor origin and growth pattern affect preoperative BMI_Z and postoperative weight gain. Despite little or no hypothalamic involvement at diagnosis, surgical damage contributes to postoperative weight gain in patients with craniopharyngioma.
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