ArticleFrontiers in endocrinology2013
Biological rhythms and preeclampsia.
Article in Frontiers in endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Embryonic Circadian Rhythm Establishment, Homeostasis, and Dysfunction During Organogenesis.Stem cells international · 2025Review
- Causal pathways in preeclampsia: a Mendelian randomization study in European populations.Frontiers in endocrinology · 2024Article
- Circadian Disruption and the Molecular Clock in Atherosclerosis and Hypertension.The Canadian journal of cardiology · 2023Review
- Exposure to unmethylated CpG oligonucleotides disrupts blood pressure circadian rhythms and placental clock gene network in pregnant rats.American journal of physiology. Heart and circulatory physiology · 2023Article
- Disruption of the Expression of the Placental Clock and Melatonin Genes in Preeclampsia.International journal of molecular sciences · 2023Article
- Morningness/eveningness in gestational diabetes mellitus: clinical characteristics and maternal-neonatal outcomes.Archives of endocrinology and metabolism · 2023Article
- Article
- Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia.Scientific reports · 2022Article
- Observational
- Identifying key genes and drug screening for preeclampsia based on gene expression profiles.Oncology letters · 2020Article
- Validation of molecular biomarkers for preoperative diagnostics of human papillary thyroid carcinoma in fine needle aspirates.Gland surgery · 2019Article
- Article
- Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature.International journal of endocrinology · 2016Review
- Article
- Human peripheral clocks: applications for studying circadian phenotypes in physiology and pathophysiology.Frontiers in neurology · 2015Review
- Circadian clocks and pregnancy.Frontiers in endocrinology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The impact of impaired circadian rhythm on health has been widely studied in shift workers and trans-meridian travelers. A part from its correlation with sleep and mood disorders, biological rhythm impairment is a recognized risk factor for cardiovascular diseases and breast cancer. Preeclampsia is a major public health issue, associated with a significant maternal and fetal morbidity and mortality worldwide. While the risks factors for this condition such as obesity, diabetes, pre-existing hypertension have been identified, the underlying mechanism of this multi-factorial disease is yet not fully understood. The disruption of the light/dark cycle in pregnancy has been associated with adverse outcomes. Slightly increased risk for "small for gestational age" babies, "low birth weight" babies, and preterm deliveries has been reported in shift working women. Whether altered circadian cycle represents a risk factor for preeclampsia or preeclampsia is itself linked with an abnormal circadian cycle is less clear. There are only few reports available, showing conflicting results. In this review, we will discuss recent observations concerning circadian pattern of blood pressure in normotensive and hypertensive pregnancies. We explore the hypothesis that circadian misalignments may represent a risk factor for preeclampsia. Unraveling potential link between circadian clock gene and preeclampsia could offer a novel approach to our understanding of this multi-system disease specific to pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.