ArticleFertility and sterility2013
Influences on endometrial development during intrauterine insemination: clinical experience of 2,929 patients with unexplained infertility.
Article in Fertility and sterility, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- The effect of endometrial PRP on fertility outcomes in women with implantation failure or thin endometrium.Archives of gynecology and obstetrics · 2025Article
- Is endometrial thickness associated with fertility outcomes in intrauterine insemination? a cohort study.Frontiers in endocrinology · 2025Article
- The impact of estradiol supplementation on endometrial thickness and intrauterine insemination outcomes.Reproductive biology · 2024Article
- Low Estradiol Level and Endometrial Thickness on the Day of Endometrial Transformation Influence Clinical Pregnancy After Intrauterine Insemination.International journal of general medicine · 2024Article
- Article
- Association between obesity and fecundity in patients undergoing intrauterine insemination.F&S reports · 2023Article
- The pregnancy outcomes of infertile women with polycystic ovary syndrome undergoing intrauterine insemination with different attempts of previous ovulation induction.Frontiers in endocrinology · 2022Article
- The value of transvaginal 4-dimensional hysterosalpingo-contrast sonography in predicting the necessity of assisted reproductive technology for women with tubal factor infertility.Quantitative imaging in medicine and surgery · 2021Article
- Comparative study of endometrial & subendometrial angiogenesis in unexplained infertile versus normal fertile women.The Indian journal of medical research · 2021Article
- Predictive factors for intrauterine insemination outcomes: a review.Fertility research and practice · 2020Review
- Article
- Intrauterine insemination as a primary viable option to infertile couples: evaluation of patients in a private center.JBRA assisted reproduction · 2019Observational
- Platelet-rich plasma therapy and reproductive medicine.Journal of assisted reproduction and genetics · 2018Article
- Relationship between bovine endometrial thickness and plasma progesterone and estradiol concentrations in natural and induced estrus.The Journal of reproduction and development · 2018Article
- A New Dawn for Intrauterine Insemination: Efficient and Prudent Practice will Benefit Patients, the Fertility Industry and the Healthcare Bodies.Journal of obstetrics and gynaecology of India · 2017Review
- Factors Leading to Pregnancies in Stimulated Intrauterine Insemination Cycles and the Use of Consecutive Ejaculations Within a Small Clinic Environment.Journal of obstetrics and gynaecology of India · 2016Article
- Minimal stimulation using gonadotropin combined with clomiphene citrate or letrozole for intrauterine insemination.Yonsei medical journal · 2015Article
- Outcomes after intrauterine insemination are independent of provider type.American journal of obstetrics and gynecology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo characterize relationships associated with adverse endometrial development in patients undergoing IUI for unexplained infertility.
designA retrospective review of 2,929 patients from 2004-2011.
settingLarge metropolitan infertility practice. PATIENT(S): Patients with unexplained infertility undergoing first IUI cycle at age less than 43 years, with a total motile sperm count ≥ 8 million. INTERVENTION(S): Clomiphene citrate (CC) with FSH stimulation followed by IUI. MAIN OUTCOME MEASURE(S): Endometrial thickness, serum E2 (in picograms per milliliter) levels on the day of hCG trigger administration, body mass index (BMI) (in kilograms per meter squared), total motile sperm, follicle number, and clinical pregnancy. RESULT(S): Of the 2,929 patients who met the inclusion criteria, 466 (15.9 %) achieved a clinical pregnancy. Pregnancy rates (PRs) increased significantly with increasing endometrial thickness on the day of hCG administration and with increasing serum E2 level, but were not significantly related to age, BMI, or follicle numbers according to multiple logistic regression modeling. Peak endometrial thickness declined with age and increasing E2 levels. The BMI was associated with thicker endometrium, but it was also associated with lower peak E2 levels. CONCLUSION(S): The impact of "endometrial factor" infertility may be underappreciated in IUI therapy. Targeted therapies to optimize the endometrium represent an important new area to improve in current fertility success rates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.