ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2013
Specific food structures supress appetite through reduced gastric emptying rate.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04812301 (Abbott Vital® as an Alternative Meal to the Gold-standard Egg-white Sandwich for Gastric Emptying Scintigraphy), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Abbott Vital® as an Alternative Meal to the Gold-standard Egg-white Sandwich for Gastric Emptying Scintigraphy (GES) Among Healthy Volunteers
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Pooled it
- Energy-dense versus routine enteral nutrition in critically ill patients: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Cinnamyl Isobutyrate Decreases Plasma Glucose Levels and Total Energy Intake from a Standardized Breakfast: A Randomized, Crossover Intervention.Molecular nutrition & food research · 2018Trial
- The sum of its parts--effects of gastric distention, nutrient content and sensory stimulation on brain activation.PloS one · 2014Trial
- The Dairy Matrix: Its Importance, Definition, and Current Application in the Context of Nutrition and Health.Nutrients · 2024Review
- Ultraprocessed Foods and Obesity Risk: A Critical Review of Reported Mechanisms.Advances in nutrition (Bethesda, Md.) · 2023Review
- The Potential Application of Pickering Multiple Emulsions in Food.Foods (Basel, Switzerland) · 2022Review
- Insights into the constellating drivers of satiety impacting dietary patterns and lifestyle.Frontiers in nutrition · 2022Review
- Dairy matrix: is the whole greater than the sum of the parts?Nutrition reviews · 2021Review
- Size and Number of Food Boluses in the Stomach after Eating Different Meals: Magnetic Resonance Imaging Insights in Healthy Humans.Nutrients · 2021Article
- WPI Gel Microstructure and Mechanical Behaviour and Their Influence on the Rate of In Vitro Digestion.Foods (Basel, Switzerland) · 2021Article
- Effects of Oro-Sensory Exposure on Satiation and Underlying Neurophysiological Mechanisms-What Do We Know So Far?Nutrients · 2021Review
- The Stomach, the Mouth, or the Food? The Puzzle of Gastric Emptying.The Journal of nutrition · 2020Article
- Current Evidence on the Bioavailability of Food Bioactive Peptides.Molecules (Basel, Switzerland) · 2020Review
- INFOGEST static in vitro simulation of gastrointestinal food digestion.Nature protocols · 2019Article
- Gastric Emptying and Dynamic In Vitro Digestion of Drinkable Yogurts: Effect of Viscosity and Composition.Nutrients · 2018Article
- Article
- Factors associated with vasovagal reactions in whole blood donors: A case-control study.Asian journal of transfusion scienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The aim of this study was to determine the extent to which gastric layering and retention of a meal could be used to reduce appetite using the same caloric load. Liquid (control) and semi-solid (active) meals were produced with the same protein, fat, carbohydrate, and mass. These were fed to 10 volunteers on separate days in a crossover study, and subjective appetite ratings, gastric contents, and plasma cholecystokinin (CCK) were assessed over a period of 3 h. The active meal showed food boluses in the stomach persisting for ~45 min, slower emptying rates, and lower plasma CCK levels over the first hour. After the first hour, both gastric emptying rates and plasma CCK levels were similar for both systems and slightly increased compared with the unfed situation. Despite the lower plasma CCK levels for the active meal over the first hour, this meal reduced appetite more than the control meal over the 3 h of the study. For a moderately increased plasma CCK level in the fed state, appetite was correlated with the volume of gastric contents rather than gastric emptying rates or plasma CCK. This suggests that enhanced gastric retention was the key factor in decreasing appetite and was probably mediated by a combination of intestinal nutrient sensing and increased viscosity in the stomach.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.