ArticleBehavioural brain research2013
Neonatal alcohol exposure impairs contextual fear conditioning in juvenile rats by disrupting cholinergic function.
Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Early developmental alcohol exposure alters behavioral outcomes following adolescent re-exposure in a rat model.Alcoholism, clinical and experimental research · 2022Article
- Neonatal ethanol causes profound reduction of cholinergic cell number in the basal forebrain of adult animals.Alcohol (Fayetteville, N.Y.) · 2021Article
- NMDA receptors and the ontogeny of post-shock and retention freezing during contextual fear conditioning.Developmental psychobiology · 2020Article
- Cholinergic rescue of neurocognitive insult following third-trimester equivalent alcohol exposure in rats.Neurobiology of learning and memory · 2019Article
- Neonatal ethanol exposure impairs long-term context memory formation and prefrontal immediate early gene expression in adolescent rats.Behavioural brain research · 2019Article
- Differential involvement of amygdalar NMDA receptors across variants of contextual fear conditioning in adolescent rats.Behavioural brain research · 2019Article
- Impairment of the context preexposure facilitation effect in juvenile rats by neonatal alcohol exposure is associated with decreased Egr-1 mRNA expression in the prefrontal cortex.Behavioral neuroscience · 2018Article
- Age and experience dependent changes in Egr-1 expression during the ontogeny of the context preexposure facilitation effect (CPFE).Neurobiology of learning and memory · 2018Article
- Differential expression of the immediate early genes c-Fos, Arc, Egr-1, and Npas4 during long-term memory formation in the context preexposure facilitation effect (CPFE).Neurobiology of learning and memory · 2018Article
- Neonatal infection produces significant changes in immune function with no associated learning deficits in juvenile rats.Developmental neurobiology · 2017Article
- Antagonism of muscarinic acetylcholine receptors in medial prefrontal cortex disrupts the context preexposure facilitation effect.Neurobiology of learning and memory · 2017Article
- Differential involvement of the medial prefrontal cortex across variants of contextual fear conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Cholinergic mechanisms of the context preexposure facilitation effect in adolescent rats.Behavioral neuroscience · 2016Article
- NMDA receptor antagonism disrupts acquisition and retention of the context preexposure facilitation effect in adolescent rats.Behavioural brain research · 2016Article
- Using the context preexposure facilitation effect to study long-term context memory in preweanling, juvenile, adolescent, and adult rats.Physiology & behavior · 2015Article
- The effects of postnatal alcohol exposure and galantamine on the context pre-exposure facilitation effect and acetylcholine efflux using in vivo microdialysis.Alcohol (Fayetteville, N.Y.) · 2015Article
- Egr-1 mRNA expression patterns in the prefrontal cortex, hippocampus, and amygdala during variants of contextual fear conditioning in adolescent rats.Brain research · 2014Article
- Neonatal alcohol impairs the context preexposure facilitation effect in juvenile rats: dose-response and post-training consolidation effects.Alcohol (Fayetteville, N.Y.) · 2014Article
- Egr-1 increases in the prefrontal cortex following training in the context preexposure facilitation effect (CPFE) paradigm.Neurobiology of learning and memory · 2013Article
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Authors and funding
3 authors.
Funding
Abstract
The context preexposure facilitation effect (CPFE) is a variant of context fear conditioning in which context preexposure facilitates conditioning to immediate foot shock. Learning about context (preexposure), associating the context with shock (training), and expression of context fear (testing) occur in successive phases of the protocol. The CPFE develops postnatally, depends on hippocampal NMDA receptor function, and is highly sensitive to neonatal alcohol exposure during the weanling/juvenile period of development [15,16]. The present study examined some behavioral and pharmacological mechanisms through which neonatal alcohol impairs the CPFE in juvenile rats. We found that a 5-min context preexposure plus five 1-min preexposures greatly increases the levels of conditioned freezing compared to a single 5-min exposure or to five 1-min preexposures (Experiment 1). Increasing conditioned freezing with the multiple- exposure CPFE protocol does not alter the neonatal alcohol-induced deficit in the CPFE (Experiment 2). Finally, systemic administration of 0.01 mg/kg physostigmine prior to all three phases of the CPFE reverses this ethanol-induced deficit. These findings show that impairment of the CPFE by neonatal alcohol is not confined to behavioral protocols that produce low levels of conditioned freezing. They also support recent evidence that this impairment reflects a disruption of cholinergic function [18].
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