ArticleBiomaterials2013
Neural progenitor cells labeling with microbubble contrast agent for ultrasound imaging in vivo.
Article in Biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Super-Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Imaging of macrophage accumulation in solid tumors with ultrasound.Nature communications · 2025Article
- Molecular imaging of cellular immunotherapies in experimental and therapeutic settings.Cancer immunology, immunotherapy : CII · 2022Review
- Intracellular vesicle entrapment of nanobubble ultrasound contrast agents targeted to PSMA promotes prolonged enhancement and stabilityNanotheranostics · 2022Article
- Biomedical nanobubbles and opportunities for microfluidics.RSC advances · 2021Review
- Options for imaging cellular therapeutics in vivo: a multi-stakeholder perspective.Cytotherapy · 2021Review
- IQF characterization of a cathepsin B-responsive nanoprobe for report of differentiation of HL60 cells into macrophages.RSC advances · 2021Article
- Fluorous-phase iron oxide nanoparticles as enhancers of acoustic droplet vaporization of perfluorocarbons with supra-physiologic boiling point.Journal of controlled release : official journal of the Controlled Release Society · 2019Article
- Listening for the therapeutic window: Advances in drug delivery utilizing photoacoustic imaging.Advanced drug delivery reviews · 2019Review
- Clinical Tracking of Cell Transfer and Cell Transplantation: Trials and Tribulations.Radiology · 2018Review
- Article
- Removal of ligand-bound liposomes from cell surfaces by microbubbles exposed to ultrasound.Journal of biological physics · 2017Article
- Use of Nanoparticle Contrast Agents for Cell Tracking with Computed Tomography.Bioconjugate chemistry · 2017Review
- Ultrasound Detection of Regional Oxidative Stress in Deep Tissues Using Novel Enzyme Loaded Nanoparticles.Advanced healthcare materials · 2017Article
- In Vivo Micro-CT Imaging of Human Mesenchymal Stem Cells Labeled with Gold-Poly-L-Lysine Nanocomplexes.Advanced functional materials · 2017Article
- Exosome-like silica nanoparticles: a novel ultrasound contrast agent for stem cell imaging.Nanoscale · 2017Article
- In vitro methods to study bubble-cell interactions: Fundamentals and therapeutic applications.Biomicrofluidics · 2016Review
- Genetic engineered molecular imaging probes for applications in cell therapy: emphasis on MRI approach.American journal of nuclear medicine and molecular imaging · 2016Review
- Stem Cell Imaging: Tools to Improve Cell Delivery and Viability.Stem cells international · 2016Review
- In Vivo Transfection and Detection of Gene Expression of Stem Cells Preloaded with DNA-carrying Microbubbles.Radiology · 2015Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Tracking neuroprogenitor cells (NPCs) that are used to target tumors, infarction or inflammation, is paramount for cell-based therapy. We employed ultrasound imaging that can detect a single microbubble because it can distinguish its unique signal from those of surrounding tissues. NPCs efficiently internalized positively charged microbubbles allowing a clinical ultrasound system to detect a single cell at 7 MHz. When injected intravenously, labeled NPCs traversed the lungs to be imaged in the left ventricle and the liver where they accumulated. Internalized microbubbles were not only less sensitive to destruction by ultrasound, but remained visible in vivo for days as compared to minutes when given free. The extended longevity provides ample time to allow cells to reach their intended target. We were also able to transfect NPCs in vitro when microbubbles were preloaded with GFP plasmid only when cells were insonated. Transfection efficiency and cell viability were both greater than 90%.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.