ArticleClinical and experimental immunology1990
Alveolar macrophages in AIDS patients: increased spontaneous tumour necrosis factor-alpha production in Pneumocystis carinii pneumonia.
Article in Clinical and experimental immunology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 83 citations in OpenAlex.
- Immune responses of different hosts toEuropean respiratory review : an official journal of the European Respiratory Society · 2025Review
- B cell production of tumor necrosis factor in response to Pneumocystis murina infection in mice.Infection and immunity · 2013Article
- Abnormalities in host defense associated with HIV infection.Clinics in chest medicine · 2013Review
- Toll-like receptor 2 mediates alveolar macrophage response to Pneumocystis murina.Infection and immunity · 2006Article
- Effect of bronchoalveolar lavage fluid from Pneumocystis carinii-infected hosts on phagocytic activity of alveolar macrophages.Infection and immunity · 2004Article
- Sensitized splenocytes result in deleterious cytokine cascade and hyperinflammatory response in rats with Pneumocystis pneumonia despite the presence of corticosteroids.Infection and immunity · 2004Article
- Constitutive expression of types 1 and 2 cytokines by alveolar macrophages from feline immunodeficiency virus-infected cats.Veterinary immunology and immunopathology · 2001Article
- Alteration in expression of the rat mitochondrial ATPase 6 gene during Pneumocystis carinii infection.BMC microbiology · 2001Article
- Immunological features of Pneumocystis carinii infection in humans.Clinical and diagnostic laboratory immunology · 1999Review
- The major surface glycoprotein of Pneumocystis carinii induces release and gene expression of interleukin-8 and tumor necrosis factor alpha in monocytes.Infection and immunity · 1997Article
- Steady-state effects of vitronectin and fibronectin on the binding, uptake, and degradation of Pneumocystis carinii in rat alveolar macrophages.Inflammation · 1997Article
- The role of alveolar macrophages in Pneumocystis carinii degradation and clearance from the lung.The Journal of clinical investigation · 1997Article
- Article
- Surfactant protein D interacts with Pneumocystis carinii and mediates organism adherence to alveolar macrophages.The Journal of clinical investigation · 1995Article
- AIDS and the lung: update 1995. 4. Role of the human immunodeficiency virus within the lung.Thorax · 1995Review
- HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.The EMBO journal · 1995Article
- Cellular responses to a 55-kilodalton recombinant Pneumocystis carinii antigen.Infection and immunity · 1994Article
- Mycobacterium avium infection in HIV-1-infected subjects increases monokine secretion and is associated with enhanced viral load and diminished immune response to viral antigens.Clinical and experimental immunology · 1994Article
- Human immunodeficiency virus type 1 infection of human macrophages modulates the cytokine response to Pneumocystis carinii.Infection and immunity · 1994Article
- HIV in the lung: guilty or not guilty?Thorax · 1993Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to assess the role of alveolar macrophages and their products in the control of Pneumocystis carinii pneumonia (PCP) and other infections in AIDS, bronchoalveolar lavage cells and peripheral blood mononuclear cells from HIV-positive AIDS/ARC patients (with and without PCP) and HIV-negative patients were counted and cultured in vitro; spontaneous and LPS-induced tumour necrosis factor-alpha (TNF-alpha) production was measured. Markedly increased spontaneous TNF-alpha production by alveolar macrophages and, to a lesser extent, peripheral blood monocytes was found in HIV-positive patients with active PCP but not in patients without the infection. Higher TNF production was associated with lower counts of Pneumocystis in the bronchoalveolar lavage fluid. These results suggest that TNF-alpha production by macrophages may play an important role in the control of Pn. carinii infection in AIDS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.