Trial reportSubstance abuse2013
Aversion to injection limits acceptability of extended-release naltrexone among homeless, alcohol-dependent patients.
Trial report in Substance abuse, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01155869 (Pilot Study of Depot Naltrexone in Alcohol-Dependent, Homeless Veterans), which is not on this map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study of Depot Naltrexone in Alcohol-Dependent, Homeless Veterans
Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Trial
- Combining behavioral harm-reduction treatment and extended-release naltrexone for people experiencing homelessness and alcohol use disorder in the USA: a randomised clinical trial.The lancet. Psychiatry · 2021Trial
- Harm reduction with pharmacotherapy for homeless people with alcohol dependence: protocol for a randomized controlled trial.Contemporary clinical trials · 2014Trial
- Barriers to initiation of extended release naltrexone among HIV-infected adults with alcohol use disorders.Journal of substance abuse treatment · 2018Article
- Survey of Treatment Preferences for Opioid Use Disorder.Jacobs journal of addiction and therapy · 2018Article
- Men Who Have Sex With Men in Peru: Acceptability of Medication-Assisted Therapy for Treating Alcohol Use Disorders.American journal of men's health · 2017Article
- Neural correlates of adherence to extended-release naltrexone pharmacotherapy in heroin dependence.Translational psychiatry · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEnding homelessness is a major priority of the Department of Veteran Affairs (VA), and alcohol use can be a barrier to stable housing. Clinical trials suggest that depot extended-release naltrexone (XR-NTX) is efficacious in reducing alcohol consumption among alcohol-dependent subjects.
methodsAn open-label, randomized pilot study sought to examine the feasibility and effectiveness of XR-NTX versus oral naltrexone to improve alcohol consumption and housing stability among homeless, alcohol-dependent veterans at the Providence Veteran Affairs Medical Center.
resultsOf 215 potential candidates approached over a 16-month recruitment period, only 15 agreed to consider study entry and 7 were randomized. The primary reasons given for refusal were not wanting an injection; fear of needles; and not wanting to change drinking habits. Only 1 participant in the XR-NTX group returned after the first injection. Three participants in the oral naltrexone group attended all 7 visits and had good outcomes.
conclusionsAlthough XR-NTX has demonstrated efficacy in reducing heavy drinking, limited acceptance of the injection might reduce its effectiveness among homeless, alcohol-dependent patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.