ArticleCritical care (London, England)2013
A new scoring system derived from base excess and platelet count at presentation predicts mortality in paediatric meningococcal sepsis.
Article in Critical care (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce.Critical care medicine · 2022Pooled it
- Base deficit and alactic base excess are promising early biological markers in pediatric sepsis.BMC pediatrics · 2026Article
- Article
- Subphenotypes of platelet count trajectories in sepsis from multi-center ICU data.Scientific reports · 2024Observational
- A nomogram to predict 28-day mortality in neonates with sepsis: a retrospective study based on the MIMIC-III database.Translational pediatrics · 2023Article
- Association between base excess and 28-day mortality in sepsis patients: A secondary analysis based on the MIMIC- IV database.Heliyon · 2023Article
- Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis.Critical care explorations · 2021Article
- Prognostic value of sepsis-induced coagulation abnormalities: an early assessment in the emergency department.Internal and emergency medicine · 2019Article
- Can Base Excess be Used for Prediction to Early Diagnosis of Neonatal Sepsis in Preterm Newborns?Mediterranean journal of hematology and infectious diseases · 2019Article
- Differences in IgG Fc Glycosylation Are Associated with Outcome of Pediatric Meningococcal Sepsis.mBio · 2018Article
- Attributable Risk and Time Course of Colistin-Associated Acute Kidney Injury.Clinical journal of the American Society of Nephrology : CJASN · 2018Article
- Rapid Accurate Identification of Tuberculous Meningitis Among South African Children Using a Novel Clinical Decision Tool.The Pediatric infectious disease journal · 2018Article
- What do sepsis-induced coagulation test result abnormalities mean to intensivists?Intensive care medicine · 2017Article
- Circadian Variation of Plasminogen-Activator-Inhibitor-1 Levels in Children with Meningococcal Sepsis.PloS one · 2016Article
- Prognostic factors in patients with septic shock in digestive surgery who have undergone direct hemoperfusion with polymyxin B-immobilized fibers: a retrospective observational study.Journal of intensive care · 2015Article
- Platelet mitochondrial membrane depolarization reflects disease severity in patients with sepsis and correlates with clinical outcome.Critical care (London, England) · 2014Article
- A simple meningococcal sepsis prognostic score: focusing on the human animal.Critical care (London, England) · 2013Article
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Authors and funding
15 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this study was to derive a novel prognostic score for mortality in paediatric meningococcal sepsis (MS) based on readily available laboratory markers.
methodsA multicentre retrospective cohort study for the consortium set and a single centre retrospective study for replication set. The consortium set were 1,073 children (age 1 week to 17.9 years) referred over a 15-year period (1996 to 2011), who had an admission diagnosis of MS, referred to paediatric intensive care units (PICUs) in six different European centres. The consortium set was split into a development set and validation set to derive the score. The replication set were 134 children with MS (age 2 weeks to 16 years) referred over a 4-year period (2007 to 2011) to PICUs via the Children's Acute Transport Service (CATS), London.
resultsA total of 85/1,073 (7.9%) children in the consortium set died. A total of 16/134 (11.9%) children in the replication set died. Children dying in the consortium set had significantly lower base excess, C-reactive protein (CRP), platelet and white cell count, more deranged coagulation and higher lactate than survivors. Paediatric risk of mortality (PRISM) score, Glasgow meningococcal septicaemia prognosis score (GMSPS) and Rotterdam score were also higher. Using the consortium set, a new scoring system using base excess and platelet count at presentation, termed the BEP score, was mathematically developed and validated. BEP predicted mortality with high sensitivity and specificity scores (area under the curve (AUC) in the validation set=0.86 and in the replication set=0.96). In the validation set, BEP score performance (AUC=0.86, confidence interval (CI): 0.80 to 0.91) was better than GMSPS (AUC=0.77, CI: 0.68, 0.85), similar to Rotterdam (AUC=0.87, CI: 0.81 to 0.93) and not as good as PRISM (AUC=0.93, CI: 0.85 to 0.97).
conclusionsThe BEP score, relying on only two variables that are quickly and objectively measurable and readily available at presentation, is highly sensitive and specific in predicting death from MS in childhood.
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